Analysis of right ventricle histopathology from human heart specimen of pulmonary arterial hyoertension

• Project/Area Number: 26860841
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Iwasa Toru 国立研究開発法人国立循環器病研究センター, 病院, 医師 (80712843)
• Research Collaborator: YAMADA Osamu ; SHIRAISHI Isao ; UEDA Hatsue
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 肺高血圧 / 右心不全 / 右室病理 / 右室リモデリング / 肺動脈性肺高血圧 / 右室線維化

Outline of Final Research Achievements

From the analysis of specimens from pulmonary arterial hypertension patients, the fibrotic area percentage in the right ventricle was significantly about 4 times larger from the normal right ventricle and small arteries in right ventricle were significantly reduced. These findings were emphasized at endocardical side of the right ventricle.The fibrotic area percentage was not correlated with the hemodynamic data of the patients, but correlated with the number of years from the beginning of the symptom to the time of diagnosis or death.
The thickness of the right coronary arteries which mainly perfuse right ventricles related to the symptom of heart failure.
To manage the pulmonary arterial hypertension better, it is important to diagnose the disease as early as possible to reduce the fibrosis of the right ventricle, and it is also important to evaluate the thickness of right coronary arteries.

Research Products

• [Journal Article] Eisenmenger症候群 (2017)
  • Author(s): 岩朝 徹
  • Journal Title: 月刊ハートナーシング(2017年春季増刊) Volume: -
• [Presentation] 肺高血圧患者の右冠動脈 (2017)
  • Author(s): 岩朝 徹
  • Organizer: 大阪小児PHフォーラム
  • Place of Presentation: 大阪
  • Year and Date: 2017-02-22
• [Presentation] 自然寛解した小児期発症重症HPAHの一例 (2017)
  • Author(s): 岩朝 徹
  • Organizer: 第23回日本小児肺循環研究会
  • Place of Presentation: 東京
  • Year and Date: 2017-02-01
• [Presentation] 肺動脈性肺高血圧患者の右冠動脈 (2017)
  • Author(s): 岩朝 徹
  • Organizer: 第2回日本肺高血圧・肺循環学会
  • Place of Presentation: 札幌
• [Presentation] 小児の二群ＰＨ (2016)
  • Author(s): 岩朝 徹
  • Organizer: 第１回日本肺高血圧・肺循環学会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-01
• [Presentation] 自然寛解した小児期発症重症HPAHの一例 (2016)
  • Author(s): 岩朝 徹
  • Organizer: 第１回日本肺高血圧・肺循環学会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-01
• [Presentation] 当科におけるほぼ無症状で発見された小児特発性・遺伝性肺動脈性肺高血圧患者の臨床像 (2016)
  • Author(s): 岩朝 徹，山田 修, 大内秀雄, 津田悦子, 白石 公
  • Organizer: 第119回日本小児科学会総会・学術集会
  • Place of Presentation: さっぽろ芸文館
  • Year and Date: 2016-04-13
• [Presentation] Keynote lecture(肺動脈性肺高血圧の右室に関して) (2016)
  • Author(s): 山田 修, 岩朝 徹
  • Organizer: 第18回日本成人先天性心疾患学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2016-01-16
• [Presentation] 肺動脈性肺高血圧死亡例の剖検心の右室病理に関する検討 (2014)
  • Author(s): 岩朝 徹、山田 修、津田 悦子、植田 初江
  • Organizer: 第36回心筋生検研究会
  • Place of Presentation: ウインクあいち
  • Year and Date: 2014-11-28
• [Presentation] 右室を見る (2014)
  • Author(s): 岩朝 徹、山田 修、植田 初江
  • Organizer: 第５０回日本小児循環器学会総会・学術集会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-07-03