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The role and kinetics of inflammation in neonatal chronic lung disease

Research Project

Project/Area Number 26860843
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Wakabayashi Kenji  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20723795)

Co-Investigator(Renkei-kenkyūsha) TAKI Atsuko  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20614481)
DOI Shouzaburoh  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80262195)
UCHIDA Tokujiro  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
Research Collaborator TAKATA Masao  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords新生児医学 / 集中治療医学 / 呼吸器病学 / 免疫学 / 生理学 / 新生児慢性肺疾患 / 炎症 / 新生児学 / 小児科学 / RSウイルス感染症 / 小児気管支喘息
Outline of Final Research Achievements

This grant was the first project for the principal investigator (PI) since he returned from the 6-year work in the UK. In the 3-year funding period, the PI successfully established his unique translational research lab at his institution, and also developed a number of research alliances both nationally and internationally. In terms of the achievement from this grant, his group produced 10 publications, 9 conference presentations, and 1 book chapters on top of the 3 new funding awarded during the 3-year period. More specifically, the group developed mouse neonatal chronic lung disease (CLD) model using hyperoxic chamber and analyzed the number and activation status of inflammatory cells in the early phase of the CLD model.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (10 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Imperial College London(United Kingdom)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury2017

    • Author(s)
      Tatham KC, O'Dea KP, Romano R, Donaldson HE, Wakabayashi K, Patel BV, Thakuria L, Simon AR, Sarathchandra P, Harefield POPSTAR investigators, Marczin N, Takata M
    • Journal Title

      Thorax

      Volume: 印刷中 Issue: 4 Pages: 350-360

    • DOI

      10.1136/thoraxjnl-2016-208977

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition Of TNF Receptor p55 By A Domain Antibody Attenuates The Initial Phase Of Acid-Induced Lung Injury In Mice2017

    • Author(s)
      Michael Wilson, Kenji Wakabayashi, Szabolcs Bertok, Charlotte Oakley, Brijesh Patel, Kieran O'Dea, Joanna Cordy, Peter Morley, Andrew Bayliffe and Masao Takata
    • Journal Title

      Frontiers in Immunology

      Volume: 8

    • DOI

      10.3389/fimmu.2017.00128

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 肺傷害は多臓器不全を惹起する?2017

    • Author(s)
      若林健二
    • Journal Title

      救急・集中治療 多臓器不全 -その常識は正しいか?-

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The role of ex vivo lung perfusion in lung transplantation2015

    • Author(s)
      Kate Tatham, Kieran O'Dea, Kenji Wakabayashi, Nandor Marczin, Masao Takata.
    • Journal Title

      Journal of the Intensive Care Society

      Volume: 1 Pages: 58-63

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] INFLUENCE OF GLUTATHIONE - S - TRANSFERASE ( GST ) INHIBITION ON LUNG 1 EPITHELIAL CELL INJURY : ROLE OF OXIDATIVE STRESS AND METABOLISM2015

    • Author(s)
      Marianne Fletcher, Piers Boshier, Kenji Wakabayashi, Hector Keun, Ryszard T. Smolenski, Paul Kirkham, Ian Adcock, Paul Barton, Masao Takata, and Nandor Marczin
    • Journal Title

      American Journal of Physiology Lung Cellular and Molecular Physiology

      Volume: April Issue: 12 Pages: 1274-1285

    • DOI

      10.1152/ajplung.00220.2014

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Post-operative cardiac arrest induced by co-administration of amiodarone and dexmedetomidine: a case report.2015

    • Author(s)
      Ohmori T, Shiota N, Haramo A, Masuda T, Maruyama F, Wakabayashi K, Adachi YU, Nakazawa K.
    • Journal Title

      J Intensive Care.

      Volume: 3 Issue: 1 Pages: 43-43

    • DOI

      10.1186/s40560-015-0109-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of ex vivo lung perfusion in lung transplantation2015

    • Author(s)
      Kate Colette Tatham, Kieran Patrick O’Dea, Kenji Wakabayashi, Nandor Marczin, and Masao Takata
    • Journal Title

      Journal of the Intensive Care Society

      Volume: 16 Issue: 1 Pages: 52-57

    • DOI

      10.1177/1751143714554062

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] SURGICAL HIGH CARE UNITにおける早期離床の現状 ~より安全かつ早期の離床を目指して~2017

    • Author(s)
      田中真莉恵、塚田容子、岡晃司、西奈緒、高橋洋子、若林健二、高橋英夫
    • Organizer
      日本集中治療医学会第1回東海北陸支部学術集会
    • Place of Presentation
      ウインクあいち (愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間質性肺炎急性増悪例の人工呼吸器設定についての検討2016

    • Author(s)
      若林健二、足立裕史、立石知也、稲瀬直彦、中沢弘一
    • Organizer
      第43回日本集中治療医学会学術集会
    • Place of Presentation
      神戸国際展示場、兵庫県神戸市
    • Year and Date
      2016-02-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Biotraumaの観点から見た肺傷害と多臓器不全のメカニズム2016

    • Author(s)
      若林健二
    • Organizer
      第38回日本呼吸療法医学会
    • Place of Presentation
      名古屋国際会議場 (愛知県、名古屋市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ventilator settings and outcome of noninvasive and invasive ventilation for patients with acute respiratory failure on chronic interstitial lung disease2016

    • Author(s)
      Kenji Wakabayashi, Tomoya Tateishi, Yushi Adachi, Naohiko Inase, Kochi Nakazawa
    • Organizer
      Ameritcan Thoracic Society International Conference 2016
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dexmedetomidine Ameliorates Monocrotaline Induced Pulmonary Arterial Hypertension in Rats2015

    • Author(s)
      Kajikawa Y, Hosokawa S, Wakabayashi K, Maejima Y, Isobe M, Doi S
    • Organizer
      American Heart Association Scientific Sessions 2015
    • Place of Presentation
      Orange County Convention Center, Orland USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] RSウイルス肺炎による呼吸不全に対してECMOを導入したが、広範囲脳梗塞のために死亡の転帰を辿った小児の一症例2015

    • Author(s)
      若林健二、丸山史、田坂有理、大森敬文、篠田健、増田孝広、中沢弘一、三高千恵子、槇田浩史
    • Organizer
      第37回呼吸療法医学会学術集会
    • Place of Presentation
      京都国際会議場、京都府京都市
    • Year and Date
      2015-07-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Dexmedetomidine ameliorates monocrotaline induced pulmonary arterial hypertension in rats2015

    • Author(s)
      梶川 優介、細川 奨、若林 健二、 前嶋 康浩、磯部 光章、土井 庄三郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Dexmedetomidine ameliorates monocrotaline induced pulmonary arterial hypertension in rats2015

    • Author(s)
      梶川優介, 若林健二, 細川奨, 前嶋康浩, 磯部光章, 土井庄三郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Volutraumaとatelectraumaでは炎症の度合いが異なる:肺血管内単球の人工呼吸器関連肺損傷における役割2015

    • Author(s)
      若林健二, Michael R Wilson, Kate C Tatham, Kieran P O'Dea, 高田正雄
    • Organizer
      第42回日本集中治療医学会学術集会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2015-02-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺高血圧症の進展におけるデクスメデトミジンの役割2015

    • Author(s)
      梶川優介 、若林健二 、細川奨 、土井庄三郎、前嶋康浩、磯部光章
    • Organizer
      第21回日本小児肺循環研究会
    • Place of Presentation
      笹川記念会館
    • Year and Date
      2015-01-31
    • Related Report
      2014 Research-status Report
  • [Book] 放射線科診療にみる医学留学へのパスポート2014

    • Author(s)
      日米医学交流財団
    • Total Pages
      327
    • Publisher
      はる書房
    • Related Report
      2014 Research-status Report
  • [Remarks] 研究者詳細

    • URL

      http://reins.tmd.ac.jp/html/100009240_ja.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京医科歯科大学研究情報データベース

    • URL

      http://reins.tmd.ac.jp/html/100009240_ja.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 研究情報データベース

    • URL

      http://reins.tmd.ac.jp/html/100009240_ja.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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