The development of new treatments for perinatal brain damage using Muse cells

Research Project

Project/Area Number	26860844
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Embryonic/Neonatal medicine
Research Institution	Nagoya University
Principal Investigator	TOSHIHIKO SUZUKI 名古屋大学, 医学部附属病院, 医員 (60711083)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	再生医療 / Muse細胞 / 新生児低酸素性虚血性脳症
Outline of Final Research Achievements	The aim of this study was to reveal the therapeutic effects of Multilineage-differentiating Stress Enduring (Muse) cells to hypoxic ischemic encephalopathy (HIE). To HIE model rats, Muse cells (Muse group), mesenchymal stem cells excluding Muse cells (non-Muse group) and saline (vehicle group) were administered intravenously. Then the confirmation of cell engraftment in various organs and behavioral experiments were performed. Muse cells were detected in injured brains even 4 weeks after intravenous administration, but non-Muse cells were not detected. Moreover compared with non-Muse group and vehicle group, Muse group were improved movement and learning impairments and behavior abnormalities even at five months old. It was suggested that Muse cells may be engrafted in the injured brain and have an effect of improving cerebral dysfunction.