New transfusion criteria for anemia of prematurity infants that based on their cerebral blood circulation.

• Project/Area Number: 26860846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: Koyano Kosuke 香川大学, 医学部附属病院, 助教 (20437685)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 新生児 / 未熟児貧血 / NIRS / TRS / 脳血液量 / 近赤外光

Outline of Final Research Achievements

We measured a change of the brain blood volume at the transfusion therapy in the anemia of prematurity using TRS and reported that an absolutely needed quantity of the cerebral blood volume decreased by transfusion.Clinical manifestations improvement effect with the transfusion was remarkable in a case with much cerebral blood volume before the transfusion.The cerebral blood volume can become the new transfusion adaptation criterion.The cerebral hypovolemia shows that there is vicarious brain increased blood volume for the progression of anemia in the background at transfusion.However, it was unexplained how increase of this cerebral blood volume occurred.We produced the increase of the cerebral blood volume with the progression of anemia by increase of the cerebral arteryal blood volume using a piglet anemia model, and it determined the cerebral venous blood apothecaries measure not to almost change even if anemia progressed.

Research Products

• [Journal Article] Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets. (2017)
  • Author(s): Kubo H, Shimono R, Nakamura S, Koyano K, Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
  • Journal Title: Neonatology Volume: 111 Issue: 3 Pages: 203-210
  • DOI: 10.1159/000450721
  • Peer Reviewed / Open Access
• [Presentation] 当院NICUにおける極低出生体重児の予後と新しい脳モニタリングについて (2016)
  • Author(s): 小谷野耕佑
  • Organizer: 平成28年度香川県周産期医療従事者研修会
  • Place of Presentation: 香川大学
  • Year and Date: 2016-11-19