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New transfusion criteria for anemia of prematurity infants that based on their cerebral blood circulation.

Research Project

Project/Area Number 26860846
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

Koyano Kosuke  香川大学, 医学部附属病院, 助教 (20437685)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords新生児 / 未熟児貧血 / NIRS / TRS / 脳血液量 / 近赤外光
Outline of Final Research Achievements

We measured a change of the brain blood volume at the transfusion therapy in the anemia of prematurity using TRS and reported that an absolutely needed quantity of the cerebral blood volume decreased by transfusion.Clinical manifestations improvement effect with the transfusion was remarkable in a case with much cerebral blood volume before the transfusion.The cerebral blood volume can become the new transfusion adaptation criterion.The cerebral hypovolemia shows that there is vicarious brain increased blood volume for the progression of anemia in the background at transfusion.However, it was unexplained how increase of this cerebral blood volume occurred.We produced the increase of the cerebral blood volume with the progression of anemia by increase of the cerebral arteryal blood volume using a piglet anemia model, and it determined the cerebral venous blood apothecaries measure not to almost change even if anemia progressed.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets.2017

    • Author(s)
      Kubo H, Shimono R, Nakamura S, Koyano K, Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
    • Journal Title

      Neonatology

      Volume: 111 Issue: 3 Pages: 203-210

    • DOI

      10.1159/000450721

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 当院NICUにおける極低出生体重児の予後と新しい脳モニタリングについて2016

    • Author(s)
      小谷野耕佑
    • Organizer
      平成28年度香川県周産期医療従事者研修会
    • Place of Presentation
      香川大学
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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