Transcriptional regulation in the developing brain that influences on the neural plasticity after maturation and its disruption mechanisms by environmental chemicals
Project/Area Number |
26860852
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Tanida Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30589453)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | エストロゲン関連受容体(ERR) / 生細胞イメージング / FRAP / FRET / 神経突起伸長 / PGC-1α / エストロゲン受容体(ER)α / エストロゲン関連受容体 (ERR) / エネルギー代謝 / 神経成長 / エストロゲン関連受容体ERR / PGC-1 / ライブセル・イメージング / 神経内分泌学 / 視床下部 / 海馬初代培養 / エストロゲン受容体 (ER) α / Thy1-GFPマウス |
Outline of Final Research Achievements |
Estrogen receptor (ER)α plays pivotal roles in normal brain development, postsynaptic plasticity, and the pathology of neuropsychiatric disorders. In this study, the roles of estrogen-related receptor (ERR), which has strong homology with ERα, in the function of ERα was analyzed. The distribution of ERR in the rat brain was also shown. Furthermore, the investigator identified the novel variant form of PGC-1α, the transcriptional coactivator of ERR from the rat hypothalamus. The function of this variant form on the ERR transactivity and its effect on the neurite outgrowth were demonstrated.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Hepatocyte growth factor/c-met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro2016
Author(s)
Ishibashi H, Tonomura H, Ikeda T, Nagae M, Sakata M, Fujiwara H, Tanida T, Mastuda K, Kawata M, Kubo T
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Journal Title
Journal of Orthopaedic Research
Volume: 34
Pages: 709-716
DOI
Related Report
Peer Reviewed
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[Journal Article] Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain2014
Author(s)
Tanida T, Tasaka K, Akahoshi E, Ishihara-Sugano M, Saito M, Kawata S, Danjo M, Tokumoto J, Mantani Y, Nagahara D, Tabuchi Y, Yokoyama T, Kitagawa H, Kawata M, Hoshi N
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Journal Title
Journal of Applied Toxicology
Volume: 34
Pages: 117-126
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Insight into the mechanism of reproductive dysfunction caused by neonicotinoid pesticides2014
Author(s)
Hoshi N, Hirano T, Omotehara T, Tokumoto J, Umemura Y, Mantani Y, Tanida T, Warita K, Tabuchi Y, Yokoyama T, Kitagawa H
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 37
Pages: 1439-1443
DOI
Related Report
Peer Reviewed
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[Presentation] Hepatocyte Growth Factor/c-Met Has Proliferation Promoting And Anti-apoptosis Effects on Rabbit Nucleus Pulposus Cells In Vitro2015
Author(s)
Hidenobu Ishibashi, Takumi Ikeda, Hitoshi Tonomura, Munehiro Sakata, Masateru Nagae, Yasuo Mikami, Hiroyoshi Fujiwara, Takashi Tanida, Ken-ichi Matsuda, Mitsuhiro Kawata, Toshikazu Kubo
Organizer
The Orthopaedic Research Society (ORS) Annual Meeting 2015, Program Book P80, Poster No. 0722
Place of Presentation
MGM Grand Hotel, LAS VEGAS
Year and Date
2015-03-28 – 2015-03-31
Related Report
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[Presentation] Intracellular dynamics of estrogen-related receptors2015
Author(s)
Taisuke Uemura, Takashi Tanida, Ken Ichi Matsuda, Yu Sakaue, Yuki Takeda, Shunji Yamada, Mitsuhiro Kawata
Organizer
Proceedings of the 120th Annual Meeting of the Japanese Association of Anatomists and the 92nd Annual Meeting of the Physiological Society of Japan (P1-286)
Place of Presentation
神戸国際会議場・展示場
Year and Date
2015-03-21 – 2015-03-23
Related Report
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[Presentation] Neural circuit of the itch to consider from the expression of gastrin-releasing peptide in the rat somatosensory systems2014
Author(s)
Keiko Takanami, Hirotaka Sakamoto, Ken Ichi Matsuda, Keita Satoh, Takashi Tanida, Shunji Yamada, Kaihei Inoue, Takumi Oti, Tatsuya Sakamoto, Mitsuhiro Kawata
Organizer
18th Congress of the International Federation of Associations of Anatomists (IFAA2014), Annals of Anatomy, 196 (2014) S1, pp. S183
Place of Presentation
Beijing, China
Year and Date
2014-08-08 – 2014-08-10
Related Report
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