| Project/Area Number |
26860854
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
SUEMATSU Makoto 慶應義塾大学, 医学部, 教授
KAJIMURA Mayumi 慶應義塾大学, 医学部, 准教授
NAKANISHI Tsuyoshi 慶應義塾大学, 医学部, 特任講師
SUGIURA Yuki 慶應義塾大学, 医学部, 特任講師
NAGAHATA Yoshiko 慶應義塾大学, 医学部, 研究員
SUGIOKA Tadao 慶應義塾大学, 医学部, 共同研究員
MATSUURA Tomomi 慶應義塾大学, 医学部, 研究員
HISHIKI Takako 慶應義塾大学, 医学部, 特任講師
MORIKAWA Takayuki 慶應義塾大学, 医学部, 特任助教
KUBO Akiko 慶應義塾大学, 医学部, 特任講師
TAKAHASHI Takao 慶應義塾大学, 医学部, 教授
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 低酸素 / 虚血 / 新生児 / アセチル基 |
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| Outline of Final Research Achievements |
We have investigated molecular mechanisms of therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy using a rat model. We have shown that hypothermia exerts its neuroprotective effects by changing cellular acetylation status through a coordinated suppression of acetyl-CoA.
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