Comprehensive study of hypothermia in neonatal hypoxic-ischemic encephalopathy

• Project/Area Number: 26860854
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Keio University
• Principal Investigator: Takenouchi Toshiki 慶應義塾大学, 医学部, 助教 (60383741)
• Research Collaborator: SUEMATSU Makoto 慶應義塾大学, 医学部, 教授 ; KAJIMURA Mayumi 慶應義塾大学, 医学部, 准教授 ; NAKANISHI Tsuyoshi 慶應義塾大学, 医学部, 特任講師 ; SUGIURA Yuki 慶應義塾大学, 医学部, 特任講師 ; NAGAHATA Yoshiko 慶應義塾大学, 医学部, 研究員 ; SUGIOKA Tadao 慶應義塾大学, 医学部, 共同研究員 ; MATSUURA Tomomi 慶應義塾大学, 医学部, 研究員 ; HISHIKI Takako 慶應義塾大学, 医学部, 特任講師 ; MORIKAWA Takayuki 慶應義塾大学, 医学部, 特任助教 ; KUBO Akiko 慶應義塾大学, 医学部, 特任講師 ; TAKAHASHI Takao 慶應義塾大学, 医学部, 教授
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 低酸素 / 虚血 / 新生児 / アセチル基

Outline of Final Research Achievements

We have investigated molecular mechanisms of therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy using a rat model. We have shown that hypothermia exerts its neuroprotective effects by changing cellular acetylation status through a coordinated suppression of acetyl-CoA.

Research Products

• [Journal Article] Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia (2015)
  • Author(s): 2.Takenouchi T, Sugiura Y, Morikawa T, Nakanishi T, Nagahata Y, Sugioka T, Honda K, Kubo A, Hishiki T, Matsuura T, Hoshino T, Takahashi T, Suematsu M, and Kajimura M
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: 35 Issue: 5 Pages: 1-12
  • DOI: 10.1038/jcbfm.2014.253
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Hypothermic intervention causes reciprocal changes in acetylated metabolites in neonatal hypoxia-ischemia (2015)
  • Author(s): Toshiki Takenouchi
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: 京都国際会館(京都府京都市)
  • Year and Date: 2015-09-26
  • Int'l Joint Research