| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is largely unclear the timing and mechanism of diffuse white matter injury, which are linked with later cognitive impairments following preterm birth. We focused on adaptation process to extrauterine environment and continuously observed changes in micro-structural complexity with brain scattering coefficient of near-infrared light (μs’). To identify clinical variables associated with brain μs’, 60 preterm and full-term infants were studied within 7 days of birth. Brain μs’ depended on variables associated with physiological maturation and pathological conditions of the brain. Further longitudinal studies need to clear the adaptation to the fetal environment including the cerebral circulation, aiming to elucidate the pathology related to cognitive impairment.
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