Analysis of the spread of cytomegalovirus in the placenta

Research Project

Project/Area Number	26860857
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Embryonic/Neonatal medicine
Research Institution	National Institute of Infectious Diseases
Principal Investigator	Yamada Soichi 国立感染症研究所, ウイルス第一部, 主任研究官 (10514119)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	経胎盤感染 / 胎盤感染
Outline of Final Research Achievements	Human cytomegalovirus (HCMV) infection to pregnant women causes congenital infection to the fetus through the placenta. The virological analysis in placenta was performed using guinea pig and guinea pig CMV (GPCMV) model. In this study, construction of a guinea pig placental trophoblast cells culture system, and co-culture system of placental cells and macrophages using the chamber system were conducted to analize the virus spread in the placenta. The culture system of trophoblast cells was not established, and the clear image of viral spread was not observed in this study.

Report

(3 results)