Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Outline of Final Research Achievements |
Neutrophils arrest in Gai2 deficient neutrophils is defective. Gai3 deficient neutrophils showed reduced transmigration but normal arrest. Gai3, but not Gai2, deficient neutrophils showed significantly reduced migration and directionality also in a microfluidic device. This suggest that the activation of Gai2 subunit or the inhibition of Gai3 subunit in deep venous thrombosis may cause the inhibition of transmigration of neutrophils from the venous wall and the exacerbation of the disease activity. The specific control of the activity of these molecules may lead to the improvement of the symptom in deep venous thrombosis with less side effects.
|