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Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

Research Project

Project/Area Number 26860874
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

ANDO Noriko  山梨大学, 総合研究部, 助教 (90345710)

Research Collaborator NAKAO Atsuhito  山梨大学, 総合研究部, 教授 (80317445)
NAKAMURA Yuki  山梨大学, 総合研究部, 講師 (90580465)
SHIMADA Shinji  山梨大学, 総合研究部, 教授 (10114505)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordscircadian / clock / IL23R / psoriasis / imiquimod / IL23receptor / 体内時計 / 乾癬 / IL-23 receptor
Outline of Final Research Achievements

The mechanistic link between psoriasis and "the circadian clock," remains unclear. This study determined whether the core circadian gene, Clock, had a regulatory role in the development of psoriasis. We compared the development of psoriasis-like skin inflammation induced by imiquimod (IMQ) between wild-type mice and mice with a loss-of-function mutation of Clock. We also compared the development of dermatitis between wild-type mice and mice with a loss-of-function mutation of Period2 (Per2), another key circadian gene that inhibits CLOCK activity. We found that Clock mutation ameliorated IMQ-induced dermatitis, whereas the Per2 mutation exaggerated IMQ-induced dermatitis, when compared with wild-type mice associated with decreased or increased IL-23 receptor (IL-23R) expression in γ/δ+ T cells, respectively. In addition, CLOCK directly bound to the promoter of IL-23R in γ/δ+ T cells. These findings established a mechanistic link between psoriasis and the circadian clock.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.2015

    • Author(s)
      Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 12 Pages: 3001-3008

    • DOI

      10.1038/jid.2015.316

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Circadian Gene Clock Regulates Psoriasis-like Skin Inflammation in Mice2015

    • Author(s)
      Noriko Ando, Yuki Nakamura, Rui Aoki, Kayoko Ishimaru, Shinji Shimada, Atsuhito Nakao
    • Organizer
      日本研究皮膚科学会 第40回 年次総会
    • Place of Presentation
      岡山コンベンションセンター(岡山・岡山)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスイミキド乾癬モデルにおける体内時計の関与2015

    • Author(s)
      安藤典子、川村龍吉、島田眞路、中尾篤人
    • Organizer
      第82回日本皮膚科学会山梨地方会
    • Place of Presentation
      セレス甲府(山梨・中巨摩郡昭和町)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Remarks] 山梨大学免疫学教室ホームページ

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/para0imm/kenkyuu/kenkyuu.php

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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