| Project/Area Number |
26860880
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Osaka Medical College (2015)
Kyoto University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚バリア機能 / 天然保湿因子 / アトピー性皮膚炎 / 皮膚天然保湿因子 / ラマン分光光度計 |
|---|
| Outline of Final Research Achievements |
In atopic dermatitis patients, compared to healthy controls, NMFs were significantly reduced over the stratum corneum all layers and were also confirmed the correlation between TEWL and pH. Further, NMFs and skin thickness were significantly reduced by a finger after long term topical steroid use as compared to the non-use group. In addition, NMFs are reduced by scratching behavior at the time of bathing, topical treatment after bathing immediately was more early improved the NMFs. We continue to integrate the case and want to analyze the pathology of intractable skin disease.
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