| Project/Area Number |
26860881
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
YANG LINGLI 大阪大学, 医学(系)研究科(研究院), 特任研究員 (40711784)
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| Co-Investigator(Renkei-kenkyūsha) |
KANEDA Mari 大阪大学, 大学院医学系研究科, 講師 (70397644)
KATAYAMA Ichiro 大阪大学, 大学院医学系研究科, 教授 (80191980)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オートファジー / 色素産生 / メラノサイト / メラニン / 皮膚 |
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| Outline of Final Research Achievements |
This study tested whether autophagy is essential for skin pigmentation and how to affect the pigmentation in skin. Using normal human epidermal melanocytes (NHEMs) and normal human epidermal keratinocytes (NHEKs), the autophagy-related factors (ATG5, ATG7) were silenced, the melanogenesis-related genes and pathways were investigated in NHEMs, and the melanosome-uptake and melanosome degradation in NHEKs were also analyzed. This study demonstrated that autophagy activity affects melanosome formation and melanin synthesis in epidermal melanocytes, and autophagy is essential in melanosome degradation in epidermal keratinocytes.
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