The analysis of the mechanism of blood coagulation system enhancement in chronic urticaria

• Project/Area Number: 26860882
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Hiroshima University
• Principal Investigator: Morioke Satoshi 広島大学, 大学病院, 病院助教 (40536679)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 蕁麻疹 / 血液凝固 / Tissue Factor

Outline of Final Research Achievements

Lipopolysaccharide(LPS) enhanced the expression of Tissue Factor(TF) on endothelial cells synergistically. This reaction occurred through histamine type 1 receptor and toll like receptor 4. TF expressed on monocytes or endothelial cells drove external coagulation system. We showed a possibility that the activated coagulation factors produced by external coagulation reaction enhanced vascular permeability through protease activated receptor 1(PAR1).

Research Products

• [Journal Article] 蕁麻疹・血管性浮腫における血液凝固系の関わり (2015)
  • Author(s): 森桶 聡、秀 道広
  • Journal Title: MB Derma Volume: 227 Pages: 15-21
• [Journal Article] Tissue factor expression on the surface of monocytes from a patient with hereditary angioedema (2014)
  • Author(s): Iwamoto K, Morioke S, Yanase Y, Uchida K, Hide M
  • Journal Title: J Dermatol Volume: 41 Issue: 10 Pages: 929-932
  • DOI: 10.1111/1346-8138.12610
  • Peer Reviewed
• [Presentation] 慢性蕁麻疹病態と血液凝固反応の関係解明 (2015)
  • Author(s): 栁瀬雄輝, 森桶 聡, 岩本和真, 平郡隆明, 内田一恵, 秀 道広
  • Organizer: 第16回Pharmaco-Hematologyシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2015-06-13
• [Presentation] 血管内皮細胞の組織因子発現に対するヒスタミンの影響 (2015)
  • Author(s): 栁瀬雄輝, 森桶 聡, 岩本和真, 平郡隆明, 内田一恵, 秀 道広
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-26
• [Presentation] 血管内皮細胞の組織因子発現に対するヒスタミンの影響 (2014)
  • Author(s): 柳瀬雄輝、森桶 聡、岩本和真、平郡隆明、内田一恵、秀 道広
  • Organizer: 第18回日本ヒスタミン学会
  • Place of Presentation: 都ホテルニューアルカイック（兵庫県尼崎市）
  • Year and Date: 2014-10-10
• [Presentation] 凝固系と遺伝性血管性浮腫 (2014)
  • Author(s): 森桶 聡、岩本和真、柳瀬雄輝、秀 道広
  • Organizer: 第51回補体シンポジウム
  • Place of Presentation: 神戸常盤大学（兵庫県神戸市）
  • Year and Date: 2014-08-23
• [Presentation] 蕁麻疹の病態における凝固・線溶系のかかわり (2014)
  • Author(s): 森桶 聡、柳瀬雄輝、平郡真記子、岩本和真、高萩俊輔、秀 道広、竹田知広、櫻井嘉彦
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2014-05-10