• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on mechanisms of cutaneous amyloid fibril formating

Research Project

Project/Area Number 26860885
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionNagasaki University

Principal Investigator

MINE Yoshiko  長崎大学, 病院(医学系), 助教 (90381235)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアミロイド / ケラチン / 弾性線維
Outline of Final Research Achievements

Amyloidosis is a group of disease that destroys cells or tissues by accumulating insoluble materials with beta-sheet structure in cells. The precise mechanisms are not fully understood yet. Using cutaneous amyloidosis, we immunohistochemically demonstrated that cytokeratin(CK) 5 was collocated with amyloid fibrils (AF) in the dermis. We succeeded to show that one of synthetic peptides covering c-terminus of CK5 could form AF. Furthermore, we found a member of extracellular matrix (ECM-X) codistributed with AF in the dermis. By in vitro AF assay with ThT, we demonstrated that recombinant ECM-X accelerated F formation of CK5-derived peptide. Taken these, cutaneous AF formation proceeds with a help of special bystander such as ECM-X. The results of this unique points of AF formation may help drug development to amyloidosis in any organs.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Pseudoxanthoma elasticum-like skin lesions with congenital erythropoietic porphyria.2014

    • Author(s)
      Mine Y., Iwanaga A., Ikehara S., Koike Y., Takamura N., Utani A.
    • Journal Title

      Eur J Dermatol

      Volume: 24 Issue: 3 Pages: 401-402

    • DOI

      10.1684/ejd.2014.2335

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 家族性アミロイドーシスの1家系2015

    • Author(s)
      上尾大輔、阿南 隆、波多野 豊、藤原作平、大久保佑美、與崎マリ子、峯 嘉子、宇谷厚志
    • Organizer
      第67回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 皮膚アミロイドはケラチン由来か?2015

    • Author(s)
      宇谷厚志、片桐文彦、佐々木隆子、野水基義、臼井 文、鍬塚さやか、峯 嘉子
    • Organizer
      第22回分子皮膚科学フォーラム
    • Place of Presentation
      ホテル日航高知旭ロイヤル(高知県・高知市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi