| Project/Area Number |
26860887
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KAN YUJI 札幌医科大学, 医学部, 助教 (50552064)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Toshiharu 札幌医科大学, 医学部, 教授 (50167706)
SUMIKAWA Yasuyuki 札幌医科大学, 医学部, 講師 (00555526)
YOKOTA Shinichi 札幌医科大学, 医学部, 教授 (10325863)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | アトピー性皮膚炎 / シスタチンA / ヘルペスウイルス / ヒトヘルペスウイルス / HaCaT細胞 / アデノウイルス / イミキモド / 皮膚バリア |
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| Outline of Final Research Achievements |
Cystatin A is present in skin and known as protein with the antiviral effect. After immunostaining cystatin A of the atopic dermatitis (AD) patients skin of 30 cases, we compared AD lesion and normal AD skin with healthy part. Both cystatin of AD skin lesion and the healthy part was found to have attenuated as compared with normal skin in expression of cystatin A. After transmitting a herpesvirus 1、2 and adenoviral type 5 to HaCaT cells, cystatin A inhibited these viral DNA and protein synthesis. It was thought to become easy to develop for herpesvirus infection including the Kaposi varicelliform eruption as a result of decrease of barrier function. Cystatin A can become the new therapy for these infections in the future.
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