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The role of regulatory T cell and IL-17producing cell in pathology of psoriasis

Research Project

Project/Area Number 26860889
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionNagoya City University

Principal Investigator

Emi Nishida  名古屋市立大学, 大学院医学研究科, 講師 (80597534)

Research Collaborator KASUYA Saori  名古屋市立大学, 大学院医学研究科・加齢環境皮膚科学, 実験助手
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords乾癬 / 制御性T細胞 / Th17細胞 / IL-17 / 制御性T細胞 / Th17細胞 / Foxp3 / IL-17 / γδT細胞 / Foxp3 / Treg
Outline of Final Research Achievements

Recently, a lot of study have been reported about the pathology of psoriasis. It remains unclear that the localization of Treg and Th17 cell in the local skin and the mechanism of action among these cells. Therefore, in this study, we examined how the localization of regulatory T cells and Th17 cells in the lesional skin of psoriasis patients and the proportion of IL-17 in the peripheral blood are related to psoriasis severity. Regarding local skin, skin biopsy was performed to prepare a frozen specimen, which was then stained with CD4, Foxp3, IL-17 and its localization and number were examined with a fluorescence microscope.The serum cytekine were determined by Cytometric Bead Array system. We analysed these factors using multiple regression analysis and finally obtained the formula: PASI score=0.31×IL-17+1.62×TNF-α+11.4 (p=0.028).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2015 2014

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Quantifying of serum IL-17A and TNF-α to estimate the formation of psoriatic skin: PASI formula2017

    • Author(s)
      Emi Nishida, Kyoko Ikumi, Shinnosuke Muramatsu, Akimichi Morita
    • Organizer
      The 76th Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Portland, Oregon, (USA)
    • Year and Date
      2017-04-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Circulating central memory T cells might be precursor of tissue resident memory T cells (TRM) in psoriasis2015

    • Author(s)
      西田絵美、粕谷沙織、村松伸之介、森田明理
    • Organizer
      米国研究皮膚科学会
    • Place of Presentation
      Atlanta, America
    • Year and Date
      2015-05-06 – 2015-05-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Circulating central memory T cells are negatively correlated with lesional Foxp3+ regulatory T cells in psoriasis patients2014

    • Author(s)
      西田絵美、粕谷沙織、西岡明子、古橋卓也、森田明理
    • Organizer
      米国研究皮膚科学会
    • Place of Presentation
      Albuquerque, ,America
    • Year and Date
      2014-05-07 – 2014-05-10
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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