| Project/Area Number |
26860894
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
KEIJI TANESE 慶應義塾大学, 医学部, 助教 (70464815)
YUKO BABA 慶應義塾大学, 医学部, 助教 (10594591)
MASAYUKI AMAGAI 慶應義塾大学, 医学部, 教授 (90212563)
YUTAKA KAWAKAMI 慶應義塾大学, 医学部, 教授 (50161287)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 悪性黒色腫 / 癌精巣抗原 / Monoacylglycerol lipase / シグナル伝達 |
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| Outline of Final Research Achievements |
Monoacylglycerol lipase, an enzyme responsible for lipid metabolism in malignant melanoma, was confirmed to be highly expressed in malignant melanoma cells than in normal melanocytes. Then, we examined the expression of MAGL in tissue malignant melanoma cases which were integrated in our hospital as a target. MAGL is predominantly expressed in the metastatic lesions than the primary lesions. And it was confirmed that the expression strength of MAGL rises with the progression of the diseases. Additionally, MAGL showed that there are many cases to admit vascular invasion in cases that have been expressed. From these findings, it is suggested that MAGL has a potential as a biomarker of tumor progression or vascular invasion in the primary lesions.
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