| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
This study analyzed the function of L type calcium channel (LTCC) on human mast cell. LTCC expressed on mast cell which cultured from human skin. Immunofluorescence staining using anti-tryptase ab and anti-LTCC ab was performed to skin of normal subject, patients of atopic dermatitis and patients of chronic spontaneous urticaria. However, there was no significant difference in each group. Function of LTCC was analyzed by studying degranulation of cultured human skin mast cell. Nifedipine, an inhibitor of LTCC, did not affect degranulation of mast cell.
Although LTCC express on human skin mast cell, the function of in vivo LTCC on mast cell is not able to make clear.
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