| Project/Area Number |
26860903
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
IMAI Yasutomo 兵庫医科大学, 医学部, 講師 (10529514)
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
TSUTSUI Hiroko 兵庫医科大学, 医学部, 教授 (40236914)
SAKAGUCHI Yoshiko 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | IL-33 / ２型自然リンパ球 / 自然リンパ球 / インターロイキン33 / ILC2 |
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| Outline of Final Research Achievements |
IL-33, a new member of the IL-1 cytokine family, is a ligand for the receptor ST2. We examined the role of IL-33, by making transgenic mice (hK14mIL33tg#1) which express IL-33 specifically in keratinocyte. Western blot analysis showed increased expression of full-length IL-33, not cleaved IL-33, in hK14mIL33tg#1 mice. Next, we generated Rag2KO/hK14mIL33tg#1 mice which lacks Th2 cells. Interestingly, Rag2KO/hK14mIL33tg#1 mice spontaneously developed atopic dermatitis. These results suggested that group2 innate lymphoid cells produce Th2 cytokines in Rag2KO/hK14mIL33tg#1 mice.
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