Expression of activation-induced cytidine deaminase in cutaneous squamous cell carcinoma

• Project/Area Number: 26860908
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YAMAGUCHI Takashi 産業医科大学, 医学部, 産業医学修練医 (40634374)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 有棘細胞癌 / 転移 / AID

Outline of Final Research Achievements

To examine whether AID (activation-induced deaminase) is expressed in human squamous cell carcinoma (SCC), we performed an anti-AID immunostaining. Forty nine SCC tumors out of 97 cases were AID positive. All tumors in 8 cases with local recurrence expressed AID. All SCC specimens in 14 cases with lymph node metastasis and 2 cases with lung metastasis were positive for anti-AID immunostaining. Taken together, AID expression may be a prognostic marker for cutaneous SCC.

Research Products

• [Journal Article] Excessive hair growth around beta-interferon injection sites for malignant melanoma. (2016)
  • Author(s): Inoue A, Yamaguchi T, Saito N, Omoto D, Ohmori S, Haruyama S, Sawada Y, Yoshioka M, Nishio D, Nakamura M
  • Journal Title: Journal of Dermatology Volume: 43 Issue: 4 Pages: 453-454
  • DOI: 10.1111/1346-8138.13224
  • Peer Reviewed
• [Journal Article] Nivolumab in the treatment of malignant melnoma: review of the literature (2015)
  • Author(s): Mashima E, Inoue A, Sakuragi Y, Yamaguchi T, Sasaki N, Hara Y, Omoto D, Ohmori S, Haruyama S, Sawada Y, Yoshioka M, Nishio D, Nakamura M
  • Journal Title: Onco Targets Ther Volume: 8 Pages: 2045-2051
  • DOI: 10.2147/ott.s62102
  • Peer Reviewed
• [Journal Article] Is Wnt5a overexpression sufficient for generating a psoriasis-like phenotype in transgenic mice? (2015)
  • Author(s): Omoto D, Yamaguchi T, Haruyama S, Kabashima-Kubo R, Yoshioka M, Nishio D, Nakamura M.
  • Journal Title: Experimental Dermatology Volume: 24 Issue: 3 Pages: 183-184
  • DOI: 10.1111/exd.12617
  • Peer Reviewed
• [Presentation] 原発巣が自然消褪した進行期悪性黒色腫の1例 (2015)
  • Author(s): 山口卓，渡部怜子，山本佳世，尾本大輔，吉岡学，中村元信
  • Organizer: 第31回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 大阪国際会議場 （大阪府 大阪市）
  • Year and Date: 2015-07-04
• [Presentation] Expression of AID in malignant melanoma with BRAFV600E mutation (2015)
  • Author(s): Nakamura M, Mashima E, Sakuragi Y, Saito N, Yamaguchi T, Watabe R, Yoshioka H, Omoto D, Hiromasa K, Haruyama S, Kubo R, Yoshioka M, Nishio D
  • Organizer: 23rd World Congress of Dermatology
  • Place of Presentation: バンクーバー （カナダ）
  • Year and Date: 2015-06-12
  • Int'l Joint Research
• [Presentation] Expression of AID in malignant melanoma with BRAFV600E mutation (2014)
  • Author(s): Omoto D, Yamaguchi T, Haruyama S, Kabashima-Kubo R, Yoshioka M, Nishio D, Nakamura M.
  • Organizer: The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ホテル阪急エキスポパーク(大阪府 吹田市）
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Expression of AID in malignant melanoma with BRAFV600E mutation (2014)
  • Author(s): Nakamura M, Omoto D, Yamaguchi T, Haruyama S, Kabashima-Kubo R, Yoshioka M, Nishio D.
  • Organizer: FEBS EMBO 2014
  • Place of Presentation: パリ (フランス）
  • Year and Date: 2014-08-30 – 2014-09-05