Sex Differences in Molecular Mechanisms of Fear Extinction

• Project/Area Number: 26860912
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Matsuda Shingo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 流動研究員 (80723246)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 恐怖消去 / 性差 / 恐怖 / 週齢差

Outline of Final Research Achievements

First, we studied sex and age differences in gene expression levels in the medial prefrontal cortex and the dorsal hippocampus after fear extinction using DNA micro array. 306 and 208 genes were expression levels > 1.5 between sexes and ages, respectively. Furthermore, bioinformatics analysis with this gene information predicted dexamethasone as drug candidate which enhances fear extinction. Indeed, dexamethasone showed a tendency to enhancement of fear extinction memory.

Research Products

• [Journal Article] Sex differences in fear extinction and involvements of extracellular signal-kinase (ERK) (2015)
  • Author(s): Matsuda shingo, Matsizawa Daisuke, Ishii Daisuke, Tomizawa Haruna, Sutoh Chihirom Shimizu Eiji
  • Journal Title: Neurobiology of Learning and Memory Volume: 123 Pages: 117-224
  • DOI: 10.1016/j.nlm.2015.05.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mehtyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus (2015)
  • Author(s): Tomizawa H, Masuzawa D, Ishii D, Matsuda S, Kawai K, Mashimo Y, Sutoh C, Shimizu E.
  • Journal Title: Gens, Brain and Behavior Volume: 14 Issue: 3 Pages: 301-309
  • DOI: 10.1111/gbb.12207
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transient contribution of left posterior parietal cortex to cognitive restructuring. (2015)
  • Author(s): Sutoh C, Matsuzawa D, Hirano Y, Yamada M, Nagaoka S, Chakraborty S, Ishii D, Matsuda S, Tomizawa H, Ito H, Tsuji H, Obata T, Shimizu E
  • Journal Title: Scientific reports Volume: 5 Pages: 9199-9199
  • Peer Reviewed / Open Access
• [Journal Article] An isolated retrieval trial before extinction session does not prevent the return of fear. (2015)
  • Author(s): Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
  • Journal Title: Behavioural brain research Volume: 287 Pages: 139-145
  • DOI: 10.1016/j.bbr.2015.03.052
  • Peer Reviewed
• [Journal Article] Effects of memory age and interval of fear extinction sessions on contextual fear extinction. (2014)
  • Author(s): Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Shimizu E
  • Journal Title: Neuroscience letters Volume: 578 Pages: 139-142
  • DOI: 10.1016/j.neulet.2014.06.054
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mehyl Donor-Deficient Diet during Developmet Can Affect Fear and Anxiety in Adultfood in C57BL/6J Mice (2014)
  • Author(s): D.Ishii, D.Matsuzawa, S.Matsuda, H.Tomizawa, C.Sutoh, E.Shimizu
  • Journal Title: PlosOne Volume: 9 Issue: 8 Pages: e105750-e105750
  • DOI: 10.1371/journal.pone.0105750
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Sex differences in dynamics of neural activation in fear extinction (2016)
  • Author(s): 松田真悟, 一戸紀孝, 須藤文和
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-07-20
• [Presentation] 恐怖消去トレーニングに伴う神経活性変動の性差 (2016)
  • Author(s): 松田真悟, 一戸紀孝, 清水栄司, 須藤文和
  • Organizer: 第37回国立精神・神経医療研究センター神経研究所研究発表会
  • Place of Presentation: 八王子セミナーハウス
  • Year and Date: 2016-03-15
• [Presentation] Transgenerational effects of methyl donors deficient diets in mice: paternal methyl donors deficient diets during development can affect fear susceptibility in male offspring mice (2015)
  • Author(s): 佐原佑治、松澤大輔、渡邊統、石井大典、松田真悟、須藤千尋、清水栄司
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-07-28
• [Presentation] Sex differences in an activation of extracellular signal-regulated kinase (ERK) following contextual fear extinction． (2014)
  • Author(s): 松田真悟, 松澤大輔, 石井大典, 富澤はるな, 清水栄司
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-13
• [Presentation] 恐怖消去学習におけるN-メチル-D-アスパラギン酸(NMDA)受容体のメス特異的な役割 (2014)
  • Author(s): 松田真悟, 松澤大輔, 石井大典, 富澤はるな, 清水栄司
  • Organizer: 第21回脳機能とリハビリテーション研究会学術大会
  • Place of Presentation: 千葉県立保健医療大学 幕張キャンパス
  • Year and Date: 2014-04-20