| Project/Area Number |
26860912
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Matsuda Shingo 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 流動研究員 (80723246)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 恐怖消去 / 性差 / 恐怖 / 週齢差 |
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| Outline of Final Research Achievements |
First, we studied sex and age differences in gene expression levels in the medial prefrontal cortex and the dorsal hippocampus after fear extinction using DNA micro array. 306 and 208 genes were expression levels > 1.5 between sexes and ages, respectively. Furthermore, bioinformatics analysis with this gene information predicted dexamethasone as drug candidate which enhances fear extinction. Indeed, dexamethasone showed a tendency to enhancement of fear extinction memory.
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