Predicting the effect of medication and parent training for Attention deficit hyperactivity disorder
| Project/Area Number |
26860913
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ishii Ayaka 東京大学, 医学部附属病院, 助教 (40609020)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ADHD / ペアレントトレーニング / 光トポグラフィー / 塩酸メチルフェ二デート / ＡＤＨＤ / 注意欠如多動性障害 / 塩酸メチルフェニデート |
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| Outline of Final Research Achievements |
I conducted a randomized controlled trial on children with ADHD using NIRS, a safe and simple method to examine brain function. Comparing the therapeutic effects after 1 month of continued MPH administration with the increase in NIRS signal before and after a single dose of MPH, they found that a larger increase in NIRS signal was associated with better therapeutic outcome. Similar results were obtained for the therapeutic effects of MPH 1 year after administration. These results indicate that it may be possible to predict the long-term effects of MPH based on the changes in NIRS signals before and after administration of a single dose. I also investigated the effect of behavioral parent training in ADHD.Parent training was more effective in reducing behavioral problems, negative parenting and parenting stress than routine clinical care alone. Maternal ADHD symptoms and responsiveness to social approval were related to the severity of behavioral problems after parent training.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial.2016
Author(s)
Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y.
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Journal Title
Neuropsychopharmacology.
Volume: ４０
Issue: 12
Pages: 2676-2685
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: A multi-channel near-infrared spectroscopy study2015
Author(s)
Okada N, Takahashi K, Nishimura Y, Koike S, Ishii-Takahashi A, Sakakibara E, Satomura Y, Kinoshita A, Takizawa R, Kawasaki S, Nakakita M, Ohtani T, Okazaki Y, Kasai K
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Journal Title
Addict Biol
Volume: 21
Issue: 2
Pages: 489-503
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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