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Predicting the effect of medication and parent training for Attention deficit hyperactivity disorder

Research Project

Project/Area Number 26860913
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

Ishii Ayaka  東京大学, 医学部附属病院, 助教 (40609020)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsADHD / ペアレントトレーニング / 光トポグラフィー / 塩酸メチルフェ二デート / ADHD / 注意欠如多動性障害 / 塩酸メチルフェニデート
Outline of Final Research Achievements

I conducted a randomized controlled trial on children with ADHD using NIRS, a safe and simple method to examine brain function. Comparing the therapeutic effects after 1 month of continued MPH administration with the increase in NIRS signal before and after a single dose of MPH, they found that a larger increase in NIRS signal was associated with better therapeutic outcome. Similar results were obtained for the therapeutic effects of MPH 1 year after administration. These results indicate that it may be possible to predict the long-term effects of MPH based on the changes in NIRS signals before and after administration of a single dose. I also investigated the effect of behavioral parent training in ADHD.Parent training was more effective in reducing behavioral problems, negative parenting and parenting stress than routine clinical care alone. Maternal ADHD symptoms and responsiveness to social approval were related to the severity of behavioral problems after parent training.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014 Other

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial.2016

    • Author(s)
      Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y.
    • Journal Title

      Neuropsychopharmacology.

      Volume: 40 Issue: 12 Pages: 2676-2685

    • DOI

      10.1038/npp.2015.128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: A multi-channel near-infrared spectroscopy study2015

    • Author(s)
      Okada N, Takahashi K, Nishimura Y, Koike S, Ishii-Takahashi A, Sakakibara E, Satomura Y, Kinoshita A, Takizawa R, Kawasaki S, Nakakita M, Ohtani T, Okazaki Y, Kasai K
    • Journal Title

      Addict Biol

      Volume: 21 Issue: 2 Pages: 489-503

    • DOI

      10.1111/adb.12224

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder; a randomized controlled trial2015

    • Author(s)
      Ayaka Ishii-Takahashi, Ryu Takizawa, Yukika Nishimura, Yuki Kawakubo, Kiyoto Kasai, Yukiko Kano
    • Journal Title

      Neuropsychopharmacology

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] fNIRS、fMRIを用いたAD/HDに関する脳機能学的薬理効果の研究up to date2015

    • Author(s)
      石井礼花
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-05 – 2015-11-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 注意欠陥多動性障害に対する治療薬の脳機能学的薬理効果の研究最前線- fNIRS、fMRIを用いた検討-2015

    • Author(s)
      石井礼花
    • Organizer
      第45回臨床神経整理学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder; a randomized controlled trial2014

    • Author(s)
      Ayaka Ishii-Takahashi, Ryu Takizawa, Yukika Nishimura, Yuki Kawakubo, Kiyoto Kasai, Yukiko Kano
    • Organizer
      The Society of Biological Psychiatry
    • Place of Presentation
      New York
    • Year and Date
      2014-05-08 – 2014-05-10
    • Related Report
      2014 Research-status Report
  • [Remarks] 注意欠如多動性障害の薬物治療効果予測の客観的指標の開発へ

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/biomarker-for-predicting-medication-effect-in-adhd.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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