Association study of schizophrenia focusing on schizophrenomimetics responsive non-coding RNAs and development dependent

• Project/Area Number: 26860916
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Jitoku Daisuke 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (10613854)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 統合失調症 / 遺伝子研究 / コラーゲン / マイクロRNA / 脈絡叢

Outline of Final Research Achievements

We focused on microRNAs responding to schizophrenomimatic glutamate receptor antagonist and examined their target genes.The subjects were a Japanese cohort(2.000 patients with schizophrenia and 2,000 control subjects).As the result, we detected a significant association between COL4A4 gene and subjects with schizophrenia which developed from 16 to 25 years old.The present findings suggest that modification of the COL4A4 gene signaling pahtway warrants further study in terms of the pathophysiology of schizophrenia.