Atypical Development of the Central Auditory System in Young Children With Autism Spectrum Disorder

• Project/Area Number: 26860919
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Yoshimura Yuko 金沢大学, 子どものこころの発達研究センター, 助教 (70597070)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: magnetoencephalography / auditory evoked field / young children / Autism Spectrum Disorder / 脳磁計（MEG) / 乳幼児 / 聴覚誘発磁場

Outline of Final Research Achievements

We investigated the auditory evoked field in 2-to-10 years old typical developing children and children with autism spectrum disorder using child custmized MEG. We showed atypical developmental pattern in auditory evoked field in children with Autism spectrum disorder.

Research Products

• [Int'l Joint Research] ワシントン大学(米国)
• [Journal Article] Atypical development of the central auditory system in young children with Autism spectrum disorder. (2016)
  • Author(s): Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G. B., Oi, M., Munesue, T., Higashida, H., Minabe, Y., Kojima, H.
  • Journal Title: Autism Research Volume: 9(2) Issue: 11 Pages: 1-11
  • DOI: 10.1002/aur.1604
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced brain signal variability in children with autism spectrum disorder during early childhood. (2016)
  • Author(s): Takahashi T, Yoshimura Y, Hiraishi H, Hasegawa C, Munesue T, Higashida H, Minabe Y, Kikuchi M.
  • Journal Title: Hum Brain Mapp. Volume: 37（3） Issue: 3 Pages: 1038-1050
  • DOI: 10.1002/hbm.23089
  • Peer Reviewed / Open Access
• [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder. (2015)
  • Author(s): Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y
  • Journal Title: Soc Cogn Affect Neurosci Volume: 10 Pages: 248-254
  • Peer Reviewed
• [Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults. (2015)
  • Author(s): Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed / Open Access
• [Journal Article] Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography. (2015)
  • Author(s): Hiraishi H, Kikuchi M, Yoshimura Y, Kitagawa S, Hasegawa C, Munesue T, Takesaki N, Ono Y, Takahashi T, Suzuki M, Higashida H, Asada M, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 69 Pages: 153-160
  • Peer Reviewed
• [Journal Article] A longitudinal study of auditory evoked field and language development in young children. (2014)
  • Author(s): Yoshimura Y, Kikuchi M, Ueno S, Shitamichi K, Remijn GB, Hiraishi H, Hasegawa C, Furutani N, Oi M, Munesue T, Tsubokawa T, Higashida H, Minabe Y
  • Journal Title: neuroImage Volume: 1 Pages: 440-447
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders. (2014)
  • Author(s): Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Nakatani H, Higashida H, Asada M, Oi M, Minabe Y.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 69 Pages: 136-144
  • Peer Reviewed
• [Journal Article] Pre-task prefrontal activation during cognitive processes in aging: a near-infrared spectroscopy study. (2014)
  • Author(s): Oboshi Y, Kikuchi M, Shimizu Y, Yoshimura Y, Hiraishi H, Okada H, Magata Y, Ouchi Y.
  • Journal Title: PLoS One Volume: 4
  • Peer Reviewed / Open Access
• [Journal Article] Somatosensory evoked field in response to visuotactile stimulation in 3- to 4-year-old children. (2014)
  • Author(s): Remijn GB, Kikuchi M, Shitamichi K, Ueno S, Yoshimura Y, Nagao K, Tsubokawa T, Kojima H, Higashida H, Minabe Y
  • Journal Title: Front Hum Neurosci. Volume: 24
  • NAID: 120006456370
  • Peer Reviewed
• [Journal Article] Relationship between brain network pattern and cognitive performance of children revealed by MEG signals during free viewing of video. (2014)
  • Author(s): Duan F, Watanabe K, Yoshimura Y, Kikuchi M, Minabe Y, Aihara K.
  • Journal Title: Brain Cogn Volume: 86 Pages: 10-16
  • Peer Reviewed
• [Journal Article] MEGからみた、子どもの脳機能研究 (2014)
  • Author(s): 吉村優子
  • Journal Title: 子どものこころと脳の発達 Volume: 5 Pages: 34-44
• [Presentation] Atypical development of the central auditory system in young children with autism spectrum disorder (2016)
  • Author(s): Yuko Yoshimura
  • Organizer: 31st Annual Meeting of Japan Biomagnetism and Bioelectromagnetics Society
  • Place of Presentation: Kanazawa
  • Year and Date: 2016-06-09
  • Int'l Joint Research
• [Presentation] Auditory evoked response to speech stimuli in young children (2015)
  • Author(s): Yuko Yoshimura
  • Organizer: Workshop on Language Disorders and Brain Science
  • Place of Presentation: Beijing ,China
  • Year and Date: 2015-08-06
  • Int'l Joint Research / Invited
• [Presentation] 幼児期の脳機能研究-自閉症スペクトラムと定型発達の比較から (2015)
  • Author(s): 吉村優子
  • Organizer: 日本赤ちゃん学会若手部会
  • Place of Presentation: 熱海
  • Year and Date: 2015-08-01
  • Invited
• [Presentation] Mental rotation: a high-level perceptual strength of young ASD children (2015)
  • Author(s): Yuko Yoshimura, Laurent Mottron, Natsumi Takesaki,Tetsuya Takahashi, Tetsu Hirosawa, Naoki Furutani,Hirotoshi Hiraishi, Chiaki Hasegawa, Sachiko Kitagawa, Yoshio Minabe, Mitsuru Kikuchi
  • Organizer: the International Society for Autism Research
  • Place of Presentation: Grand America Hotel, Salt Lake city USA
  • Year and Date: 2015-05-13 – 2015-05-16
• [Presentation] Mental rotation: a high-level perceptual strength of young ASD children (2015)
  • Author(s): Yuko Yoshimura
  • Organizer: International Meeting for Autism Research
  • Place of Presentation: Salt Lake city, U.S.A.
  • Year and Date: 2015-05-13
  • Int'l Joint Research
• [Presentation] 幼児期の言語発達に関連する脳機能研究 (2014)
  • Author(s): 吉村優子
  • Organizer: 金沢大学子どものこころサミット
  • Place of Presentation: 北國新聞赤羽ホール、金沢
  • Year and Date: 2014-11-27 – 2014-11-29
• [Presentation] 幼児の人の声に対する脳反応と言語能力の関係：幼児用脳磁計（MEG）を用いた縦断的研究 (2014)
  • Author(s): 吉村優子
  • Organizer: 日本コミュニケーション障害学会
  • Place of Presentation: 金沢大学、金沢
  • Year and Date: 2014-05-10 – 2014-05-11
• [Remarks] 子どものこころの発達研究センター 研究業績
  • URL: http://kodomokokoro.w3.kanazawa-u.ac.jp/menu_03/04.html