Serotonin system abnormalities and activated micrglia in anorexia nervosa: a PET study.

• Project/Area Number: 26860921
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Yokokura Masamichi 浜松医科大学, 医学部, 助教 (00529399)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経性無食欲症 / 活性化ミクログリア / セロトニントランスポーター / PET

Outline of Final Research Achievements

Anorexia nervosa (AN) is a psychiatric disorder characterized by a low body weight and abnormal perception of a body shape. Previous studies indicated abnormalities of neuroinflammation and serotonin (5-HT) system in AN patients. Here, we aimed to clarify an alteration of activated microglia, which plays a major role in the neuroinflammation in living human brain, and 5-HT transporter (5-HTT) in AN using positron emission tomography (PET).
Twenty female AN patients (mean age±SD, 25.0±6.0 years old, mean BMI±SD, 14.1±1.3) and 20 healthy female subjects (22.8±3.7years old, BMI 20.6±2.4) underwent activated microglia and 5-HTT PET measurements and neurocognitive tasks. We showed increased activated microglia and reduced 5-HTT availability in AN patients.

Research Products

• [Journal Article] Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195 (2016)
  • Author(s): 7.Masamichi Yokokura, Tatsuhiro Terada, Tomoyasu Bunai, Kyoko Nakaizumi, Kiyokazu Takebayashi, Yasuhide Iwata, Etsuji Yoshikawa, Masami Futatsubashi, Katsuaki Suzuki, Norio Mori, Yasuomi Ouchi,
  • Journal Title: J Cereb Blood Flow Metab Volume: Apr 26
  • Peer Reviewed
• [Presentation] In vivo PET study of microglial activation in aging and dementia using 1st- and 2nd-generation TSPO PET tracers: [11C] (R)PK11195 and [11C]DPA713. (2016)
  • Author(s): Yokokura M
  • Organizer: The 16th conference of peace through mind/brain science
  • Place of Presentation: 浜松市
  • Year and Date: 2016-02-23
  • Int'l Joint Research
• [Presentation] A comparison study of microglial activation in aging and dementia between first- and second-generation TSPO PET tracers: [11C]PK11195 and [11C]DPA713. (2015)
  • Author(s): 4．Yokokura M, Ouchi Y, Takebayashi K, Yoshikawa E, Futatsubashi M, Iwata Y, Terada T, Nakaizumi K, Bunai T, Mori N
  • Organizer: Neuroscience 2015
  • Place of Presentation: シカゴ
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] A new PET tracer [11C]DPA713 has a higher binding to activated microglia than the common tracer [11C]PK11195 in the living human brain. (2014)
  • Author(s): Masamichi Yokokura, Yasuomi Ouchi, Kiyokazu Takebayashi, Yasuhide Iwata, Tatsuhiro Terada, Kyoko Nakaizumi, Norio Mori
  • Organizer: Neuroscience2014
  • Place of Presentation: ワシントン
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Difference in the binding of PET tracers [11C]DPA713 and [11C]PK11195 for activated microglial in the living human brain. (2014)
  • Author(s): Masamichi Yokokura, Yasuomi Ouchi, Kiyokazu Takebayashi, Etsuji Yoshikawa, Masami Futatsubashi, Yasuhide Iwata, Tatsuhiro Terada, Kyoko Nakaizumi, Norio Mori
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11 – 2014-09-13
• [Book] 脳21 Vol.18, No.2 (2015)
  • Author(s): 横倉正倫
  • Total Pages: 107
  • Publisher: 金芳堂