| Project/Area Number |
26860921
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経性無食欲症 / 活性化ミクログリア / セロトニントランスポーター / PET |
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| Outline of Final Research Achievements |
Anorexia nervosa (AN) is a psychiatric disorder characterized by a low body weight and abnormal perception of a body shape. Previous studies indicated abnormalities of neuroinflammation and serotonin (5-HT) system in AN patients. Here, we aimed to clarify an alteration of activated microglia, which plays a major role in the neuroinflammation in living human brain, and 5-HT transporter (5-HTT) in AN using positron emission tomography (PET).
Twenty female AN patients (mean age±SD, 25.0±6.0 years old, mean BMI±SD, 14.1±1.3) and 20 healthy female subjects (22.8±3.7years old, BMI 20.6±2.4) underwent activated microglia and 5-HTT PET measurements and neurocognitive tasks. We showed increased activated microglia and reduced 5-HTT availability in AN patients.
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