• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Quantitative evaluation of pain threshold and psychiatric assessment targeted at patients of pain disorder in the orofacial region.

Research Project

Project/Area Number 26860923
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionNagoya University

Principal Investigator

TOKURA Tatsuya  名古屋大学, 医学部附属病院, 助教 (20378136)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords疼痛性障害 / 口腔領域 / 口腔内灼熱症候群 / 温冷覚閾値 / 人格傾向 / デュロキセチン / 血中濃度 / 神経炎症関連物質 / サイトカイン / 抑うつ
Outline of Final Research Achievements

I evaluated the pain threshold (or warm and/or cold threshold) and assessed the psychiatric feature targeted at patients of pain disorder in the orofacial region. As a result, the followings were revealed. The cold threshold of patients descended with the advance of age. The cold threshold of female patients was significantly higher than that of male patients. Burning mouth syndrome patients had a characteristic personality trait that made them more likely to be timidly and be afraid of starting a new thing. No relationship existed between the pain-relieving effects of duloxetine and its plasma concentrations. Some neuroinflammation-related substances levels differed between patients and controls, and also before and after the treatment.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Duloxetine plasma concentrations and its effectiveness in the treatment of nonorganic chronic pain in the orofacial region.2017

    • Author(s)
      ・Kobayashi Y, Nagashima W, Tokura T, Yoshida K, Umemura E, Miyauchi T, Arao M, Ito M, Kimura H, Kurita K, Ozaki N.
    • Journal Title

      Clin Neuropharmacol.

      Volume: 40 Issue: 4 Pages: 163-168

    • DOI

      10.1097/wnf.0000000000000225

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢期のいわゆる心因性口腔症状2016

    • Author(s)
      徳倉達也
    • Journal Title

      老年精神医学

      Volume: 27 Pages: 1065-1070

    • Related Report
      2016 Research-status Report
  • [Journal Article] 口腔領域の慢性疼痛と抑うつ2016

    • Author(s)
      徳倉達也
    • Journal Title

      Depression Journal

      Volume: 4 Pages: 20-21

    • Related Report
      2016 Research-status Report
  • [Journal Article] Five patients with burning mouth syndrome in whom an antidepressant (SNRI) was not effective, but pregabalin markedly relieved pain2015

    • Author(s)
      Mikiko Ito、Tatsuya Tokura、Keizo Yoshida、Wataru Nagashima、Hiroyuki Kimura、Eri Umemura、Masako Tachibana、Tomoya Miyauchi、Yuka Kobayashi、Munetaka Arao、Norio Ozaki、Kenichi Kurita
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44 Issue: 4 Pages: 311-317

    • DOI

      10.1097/wnf.0000000000000093

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 口腔領域の非器質性慢性疼痛の治療戦略と薬物療法.2015

    • Author(s)
      徳倉達也, 木村宏之, 尾崎紀夫.
    • Journal Title

      臨床精神薬理.

      Volume: 18 Pages: 431-438

    • Related Report
      2014 Research-status Report
  • [Journal Article] Preoperative Level of Depression is a Predictor of Postoperative Levels of Depression in Patients with Head and Neck Cancer.2014

    • Author(s)
      Yasunori Adachi, Hiroyuki Kimura, Naohiro Sato, Wataru Nagashima, Kouki Nakamura, Branko Aleksic, Keizo Yoshida, Yasushi Fujimoto, Tsutomu Nakashima, Norio Ozaki
    • Journal Title

      J Psychosomatic Res.

      Volume: 44 Issue: 5 Pages: 311-317

    • DOI

      10.1016/j.jpsychores.2015.02.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Our liaison clinic: comparison of oral psychosomatic disorders at an interval of 10 years2017

    • Author(s)
      Umemura E, Ito M, Tokura T, Nagashima W, Kimura H, Kobayashi Y, Miyauchi M, Arao M, Ozaki N, Kurita K.
    • Organizer
      第23回国際顎顔面口腔外科学会議
    • Place of Presentation
      Wan Chai (Hong Kong)
    • Year and Date
      2017-03-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 18年の歴史をもつ当リエゾン歯科医療グループの現状と課題2017

    • Author(s)
      ・伊藤幹子, 徳倉達也, 梅村理恵, 朴曾士, 荒尾宗孝, 長島渉, 木村宏之, 栗田賢一.
    • Organizer
      第42回日本口腔外科学会中部支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔領域の疼痛性障害における抗うつ薬治療下での神経炎症関連物質の経時変化.2017

    • Author(s)
      ・宮内倫也, 徳倉達也, 木村宏之, 長島渉, 立花昌子, 小林由佳, 伊藤陽菜, 梅村恵理, 伊藤幹子,栗田賢一, 尾崎紀夫.
    • Organizer
      第113回日本精神神経学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔領域の疼痛性障害患者における温冷覚閾値の測定.2017

    • Author(s)
      ・徳倉達也, 宮内倫也, 木村宏之, 梅村恵理, 伊藤幹子, 佐藤曾士, 長島渉, 小林由佳, 荒尾宗孝,栗田賢一, 尾崎紀夫.
    • Organizer
      第30回日本総合病院精神医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯科医師に求められる神経障害性疼痛に対する知識と診療上の注意点2016

    • Author(s)
      徳倉達也, 伊藤幹子.
    • Organizer
      神経障害性疼痛関連歯科学会合同シンポジウム2016
    • Place of Presentation
      慶應義塾大学(東京都新宿区)
    • Year and Date
      2016-12-11
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 口腔心身症患者の臨床統計的調査‐18年間1136例の報告‐2016

    • Author(s)
      ・梅村恵理, 伊藤幹子, 木村宏之, 徳倉達也, 長島渉, 荒尾宗孝, 栗田賢一.
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔内慢性疼痛疾患における末梢血中ユビキチン化セロトニントランスポーターの発現変化2016

    • Author(s)
      ・毛利彰宏, 近藤麻生, 木村真理, 柳本佳南, 横山美里, 椿井朋, 後藤綾, 肥田祐丈, 木村宏之, 岩本邦弘, 吉見陽, 徳倉達也, 尾崎紀夫, 鍋島俊隆, 野田幸裕.
    • Organizer
      第13回日本うつ病学会総会
    • Place of Presentation
      ウインクあいち(愛知県名古屋市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Research-status Report
  • [Presentation] The treatment pathway of chronic orofacial pain triggered by dental treatment - relieving effect and concurrent depressive symptoms of duloxetine treatment.2015

    • Author(s)
      Umemura E, Ito M, Tokura T, Nagshima W, Kimura H, Kobayashi Y, Tachibana M, Miyauchi T, Arao M, Ozaki N, Kurita K.
    • Organizer
      第22回国際顎顔面口腔外科学会議.
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Melbourne, Australia)
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 30年に及ぶ当講座の口腔内灼熱症候群の治療変遷―口腔乾燥症・舌痛症対策を含んで―.2015

    • Author(s)
      伊藤幹子, 徳倉達也, 梅村恵理, 木村宏之, 荒尾宗孝, 栗田賢一.
    • Organizer
      第60回日本口腔外科学会総会.
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経障害性疼痛の治療上の問題点 ~関連医科との連携における問題点.2015

    • Author(s)
      徳倉達也, 伊藤幹子.
    • Organizer
      神経障害性疼痛関連歯科学会合同シンポジウム.
    • Place of Presentation
      慶應義塾大学病院 (東京都新宿区)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 口腔内慢性疼痛群における抑うつ状態のバイオマーカー探索.2015

    • Author(s)
      宮内倫也, 徳倉達也, 木村宏之, 長島渉, 立花昌子, 小林由佳, 伊藤陽菜, 梅村恵理, 伊藤幹子, 栗田賢一, 尾崎紀夫.
    • Organizer
      第12回日本うつ病学会総会・第15回日本認知療法学会.
    • Place of Presentation
      京王プラザホテル (東京都新宿区)
    • Year and Date
      2015-07-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔内の慢性疼痛や違和感を訴える患者の診療のエッセンス ~精神科医の立場から~.2015

    • Author(s)
      徳倉達也.
    • Organizer
      第28回日本顎関節学会・第20回日本口腔顔面痛学会.
    • Place of Presentation
      名古屋国際会議場 (愛知県名古屋市)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 口腔顔面領域における疼痛性障害に対するDuloxetineの疼痛軽減効果と血中濃度の関連について.2014

    • Author(s)
      小林由佳, 長島渉, 徳倉達也, 木村宏之, 伊藤幹子, 荒尾宗孝, 宮内倫也, 梅村恵理, 立花昌子, 栗田賢一, 尾崎紀夫.
    • Organizer
      第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会.
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 血小板におけるユビキチン化セロトニントランスポーターの発現とパーソナリティとの関連性.2014

    • Author(s)
      横山美里, 毛利彰宏, 木村真理, 椿井朋, 肥田裕丈, 木村宏之, 徳倉達也, 吉見陽, 河野直子, 國本正子, 尾崎紀夫, 鍋島俊隆, 野田幸裕.
    • Organizer
      第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会.
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Psychiatric profiles of patients with oral psychosomatic disorders - 16-year study in Japan.2014

    • Author(s)
      Umemura E, Ito M, Nagashima W, Tokura T, Kimura H, Arao M, Kobayashi Y, Miyauchi T, Ozaki N, Kurita K.
    • Organizer
      第2回日米韓合同口腔外科学会.
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 末梢血におけるセロトニントランスポーターの代謝調節と情動性の関連解析.2014

    • Author(s)
      毛利彰宏, 横山美里, 木村真理, 椿井 朋, 肥田裕丈, 木村宏之, 徳倉達也, 吉見陽, 河野直子, 國本正子, 尾崎紀夫, 鍋島俊隆, 野田幸裕.
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2014.
    • Place of Presentation
      近畿大学東大阪キャンパス(東大阪市)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi