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Impaired social functioning in patients with schizophrenia and GWAS

Research Project

Project/Area Number 26860924
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

Fujino Haruo  大阪大学, 人間科学研究科, 助教 (20707343)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords統合失調症 / 社会機能 / 認知機能 / QoL / 社会機能障害 / 認知機能障害
Outline of Final Research Achievements

Cognitive impairment and psychiatric symptoms are known as major factor that affect patient's social functioning. Additionally, social skills is a critically involved with social functioning. We investigated relationships between these variables in patients with schizophrenia and healthy individuals. The results implied cognitive function affect social skills and social functioning, which lead to a poor quality of life in patients. We also examined the relationship between brain volume and social function in patients with schizophrenia and healthy individuals. The findings suggested that brain volume may play a critical role on social function in schizophrenia.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Predicting employment status and subjective quality of life in patients with schizophrenia.2015

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
    • Journal Title

      Schizophrenia Research: Cognition

      Volume: 3 Pages: 20-25

    • DOI

      10.1016/j.scog.2015.10.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications2015

    • Author(s)
      Matsuura Y, Fujino H, Hashimoto R, Yasuda Y, Yamamori H, Ohi K, Takeda M, Imura O.
    • Journal Title

      Gait & Posture

      Volume: in press Issue: 3 Pages: 847-851

    • DOI

      10.1016/j.gaitpost.2015.03.006

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 統合失調症の認知機能障害の神経科学基盤2015

    • Author(s)
      藤野陽生, 安田由華, 山森英長, 藤本美智子, 大井一高, 福永雅喜, 武田雅俊, 橋本亮太.
    • Journal Title

      臨床精神薬理

      Volume: 18 Pages: 1519-1526

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Postural sway and clinical characteristics in patients with psychotic disorders: A review.2015

    • Author(s)
      Fujino H, Imura O
    • Journal Title

      Psychiatric Quarterly

      Volume: 86 Issue: 4 Pages: 603-614

    • DOI

      10.1007/s11126-015-9355-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes.2014

    • Author(s)
      Ohi K, Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
    • Journal Title

      Schizophr Bull.

      Volume: 41 Issue: 4 Pages: 909-18

    • DOI

      10.1093/schbul/sbu171

    • NAID

      40020682401

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia.2014

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: in press Issue: 7 Pages: 534-541

    • DOI

      10.1111/pcn.12165

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 統合失調の皮質下体積と認知機能の相関解析2016

    • Author(s)
      越山太輔,福永雅喜,岡田直大,山森英長,安田由華,藤本美智子,山下典生,藤野陽生,渡邉嘉之,住吉チカ,住吉太幹,笠井清登,橋本亮太
    • Organizer
      第11回日本統合失調症学会
    • Place of Presentation
      群馬
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調の皮質下体積と認知機能の相関解析2015

    • Author(s)
      越山太輔,福永雅喜,岡田直大,山下典生,山森英長,安田由華,藤本美智子,大井一高,藤野陽生,笠井清登,橋本亮太
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 統合失調症患者と健常者の意味記憶構造の比較:カテゴリ流暢性課題に基づく推定.2015

    • Author(s)
      住吉チカ,藤野陽生,住吉太幹,橋本亮太
    • Organizer
      日本心理学会第79回大会
    • Place of Presentation
      愛知
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Social functioning predicts subjective quality of life in patients with schizophrenia.2015

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Brief versions of the Wechsler Intelligence Scale for schizophrenia: Relation to functional outcome.2015

    • Author(s)
      Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes.2015

    • Author(s)
      Hashimoto R , Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Intermediate phenotype strategy for discovering disease related gene network.2015

    • Author(s)
      Hashimoto R, Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Fujino H, Watanabe Y, Iwata N, Takeda M.
    • Organizer
      The 12th World Congress of Biological Psychiatry
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predicting social functioning and subjective quality of life in patients with schizophrenia.2015

    • Author(s)
      Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
    • Organizer
      WPA Regional Congress 2015
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes2014

    • Author(s)
      Hashimoto R , Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
    • Organizer
      American College of Neuropsychopharmacology 53rd Annual Meeting,
    • Place of Presentation
      JW Marriott Desert Ridge Resort, Phoenix, Arizona, USA
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 精神病性障害における臨床症状と身体動揺2014

    • Author(s)
      藤野陽生
    • Organizer
      日本心理学会第78回大会
    • Place of Presentation
      同志社大学, 京都
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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