Impaired social functioning in patients with schizophrenia and GWAS

• Project/Area Number: 26860924
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Fujino Haruo 大阪大学, 人間科学研究科, 助教 (20707343)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 統合失調症 / 社会機能 / 認知機能 / QoL / 社会機能障害 / 認知機能障害

Outline of Final Research Achievements

Cognitive impairment and psychiatric symptoms are known as major factor that affect patient's social functioning. Additionally, social skills is a critically involved with social functioning. We investigated relationships between these variables in patients with schizophrenia and healthy individuals. The results implied cognitive function affect social skills and social functioning, which lead to a poor quality of life in patients. We also examined the relationship between brain volume and social function in patients with schizophrenia and healthy individuals. The findings suggested that brain volume may play a critical role on social function in schizophrenia.

Research Products

• [Journal Article] Predicting employment status and subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Ysuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Journal Title: Schizophrenia Research: Cognition Volume: 3 Pages: 20-25
  • DOI: 10.1016/j.scog.2015.10.005
  • Peer Reviewed / Open Access
• [Journal Article] Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications (2015)
  • Author(s): Matsuura Y, Fujino H, Hashimoto R, Yasuda Y, Yamamori H, Ohi K, Takeda M, Imura O.
  • Journal Title: Gait & Posture Volume: in press Issue: 3 Pages: 847-851
  • DOI: 10.1016/j.gaitpost.2015.03.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 統合失調症の認知機能障害の神経科学基盤 (2015)
  • Author(s): 藤野陽生, 安田由華, 山森英長, 藤本美智子, 大井一高, 福永雅喜, 武田雅俊, 橋本亮太.
  • Journal Title: 臨床精神薬理 Volume: 18 Pages: 1519-1526
• [Journal Article] Postural sway and clinical characteristics in patients with psychotic disorders: A review. (2015)
  • Author(s): Fujino H, Imura O
  • Journal Title: Psychiatric Quarterly Volume: 86 Issue: 4 Pages: 603-614
  • DOI: 10.1007/s11126-015-9355-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. (2014)
  • Author(s): Ohi K, Hashimoto R, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
  • Journal Title: Schizophr Bull. Volume: 41 Issue: 4 Pages: 909-18
  • DOI: 10.1093/schbul/sbu171
  • NAID: 40020682401
  • Peer Reviewed / Open Access
• [Journal Article] Performance on the Wechsler Adult Intelligence Scale-III in Japanese patients with schizophrenia. (2014)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Umeda-Yano S, Higuchi A, Hibi Y, Matsuura Y, Hashimoto R, Takeda M, Imura O.
  • Journal Title: Psychiatry Clin Neurosci. Volume: in press Issue: 7 Pages: 534-541
  • DOI: 10.1111/pcn.12165
  • Peer Reviewed
• [Presentation] 統合失調の皮質下体積と認知機能の相関解析 (2016)
  • Author(s): 越山太輔，福永雅喜，岡田直大，山森英長，安田由華，藤本美智子，山下典生，藤野陽生，渡邉嘉之，住吉チカ，住吉太幹，笠井清登，橋本亮太
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: 群馬
  • Year and Date: 2016-03-25
• [Presentation] 統合失調の皮質下体積と認知機能の相関解析 (2015)
  • Author(s): 越山太輔，福永雅喜，岡田直大，山下典生，山森英長，安田由華，藤本美智子，大井一高，藤野陽生，笠井清登，橋本亮太
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会 合同年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] 統合失調症患者と健常者の意味記憶構造の比較：カテゴリ流暢性課題に基づく推定. (2015)
  • Author(s): 住吉チカ，藤野陽生，住吉太幹，橋本亮太
  • Organizer: 日本心理学会第79回大会
  • Place of Presentation: 愛知
  • Year and Date: 2015-09-22
• [Presentation] Social functioning predicts subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Brief versions of the Wechsler Intelligence Scale for schizophrenia: Relation to functional outcome. (2015)
  • Author(s): Sumiyoshi C, Fujino H, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes. (2015)
  • Author(s): Hashimoto R , Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Intermediate phenotype strategy for discovering disease related gene network. (2015)
  • Author(s): Hashimoto R, Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Fujino H, Watanabe Y, Iwata N, Takeda M.
  • Organizer: The 12th World Congress of Biological Psychiatry
  • Place of Presentation: Athens, Greece
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] Predicting social functioning and subjective quality of life in patients with schizophrenia. (2015)
  • Author(s): Fujino H, Sumiyoshi C, Sumiyoshi T, Yasuda Y, Yamamori H, Ohi K, Fujimoto M, Hashimoto R, Takeda M, Imura O.
  • Organizer: WPA Regional Congress 2015
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes (2014)
  • Author(s): Hashimoto R , Ohi K, Ikeda M, Yamamori H, Yasuda Y, Fujimoto M, Umeda-Yano S, Fukunaga M, Fujino H, Watanabe Y, Iwase M, Kazui H, Iwata N, Weinberger DR, Takeda M.
  • Organizer: American College of Neuropsychopharmacology 53rd Annual Meeting,
  • Place of Presentation: JW Marriott Desert Ridge Resort, Phoenix, Arizona, USA
  • Year and Date: 2014-12-07 – 2014-12-11
• [Presentation] 精神病性障害における臨床症状と身体動揺 (2014)
  • Author(s): 藤野陽生
  • Organizer: 日本心理学会第78回大会
  • Place of Presentation: 同志社大学, 京都
  • Year and Date: 2014-09-10 – 2014-09-12