Study for the establishment of novel and specific treatment for PTSD, which is based on pathological mechanism
| Project/Area Number |
26860926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
KONDO Makoto 大阪大学, 医学(系)研究科(研究院), 助教 (50633012)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | セロトニン / 5-HT受容体 / 恐怖記憶 / 情動 |
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| Outline of Final Research Achievements |
We analyzed the relationship between fear memory processes and serotonin by using genetically engineered mice. Behavioral analysis of fear conditioning test revealed that the 5-HT3 receptor-deficient (htr3a-/-) mice showed intact acquisition and retention of fear memory, but impaired fear extinction. We found that 5-HT3 receptor is essential for fear extinction, and htr3a-/- mice could be a useful animal model of PTSD. Exercise has a variety of effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Exercise enhances hippocampal neurogenesis, induces antidepressant effects, and improves learning behavior. Detailed histological and behavioral analyses of htr3a-/- mice revealed that 5-HT3 receptor is indispensable for exercise-induced hippocampal neurogenesis and antidepressant effects, but not for learning enhancement.
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Report
(3 results)
Research Products
(40 results)
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[Journal Article] Authentic role of ATP signaling in micturition reflex.2016
Author(s)
Takezawa K, Kondo M, Kiuchi H, Ueda N, Soda T, Fukuhara S, Takao T, Miyagawa Y, Tsujimura A, Matsumoto-Miyai K, Ishida Y, Negoro H, Ogawa O, Nonomura N, Shimada S.
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Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 19585-19585
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] 5-HT3 receptor expression in the mouse vestibular ganglion2014
Author(s)
Takimoto Y, Ishida Y, Nakamura Y, Kamakura T, Yamada T, Kondo M, Kitahara T, Uno A, Imai T, Horii A, Okazaki S, Nishiike S, Inohara H, Shimada S
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Journal Title
Brain Res
Volume: 1557
Pages: 74-82
DOI
Related Report
Peer Reviewed
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[Presentation] A novel mechanism of infection-induced bladder hyperactivity: Lipopolysaccharide causes rapid ATP release from urothelium and stimulates the mechanosensory afferent pathway2015
Author(s)
Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Shinichiro Fukuhara, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Kazumasa Matsumoto-Miyai, Shoichi Shimada and Norio Nonomura.
Organizer
American Urological Association (AUA) Annual Meeting 2015
Place of Presentation
New Orleans, LA, USA
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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