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Study for the establishment of novel and specific treatment for PTSD, which is based on pathological mechanism

Research Project

Project/Area Number 26860926
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

KONDO Makoto  大阪大学, 医学(系)研究科(研究院), 助教 (50633012)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsセロトニン / 5-HT受容体 / 恐怖記憶 / 情動
Outline of Final Research Achievements

We analyzed the relationship between fear memory processes and serotonin by using genetically engineered mice. Behavioral analysis of fear conditioning test revealed that the 5-HT3 receptor-deficient (htr3a-/-) mice showed intact acquisition and retention of fear memory, but impaired fear extinction. We found that 5-HT3 receptor is essential for fear extinction, and htr3a-/- mice could be a useful animal model of PTSD. Exercise has a variety of effects on brain structure and function, such as hippocampal neurogenesis, mood and memory. Exercise enhances hippocampal neurogenesis, induces antidepressant effects, and improves learning behavior. Detailed histological and behavioral analyses of htr3a-/- mice revealed that 5-HT3 receptor is indispensable for exercise-induced hippocampal neurogenesis and antidepressant effects, but not for learning enhancement.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (40 results)

All 2016 2015 2014 2013 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (28 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Authentic role of ATP signaling in micturition reflex.2016

    • Author(s)
      Takezawa K, Kondo M, Kiuchi H, Ueda N, Soda T, Fukuhara S, Takao T, Miyagawa Y, Tsujimura A, Matsumoto-Miyai K, Ishida Y, Negoro H, Ogawa O, Nonomura N, Shimada S.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 19585-19585

    • DOI

      10.1038/srep19585

    • NAID

      120005818258

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      Makoto Kondo(*Corresponding author), Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Journal Title

      Molecular Psychiatry

      Volume: 20 Issue: 11 Pages: 1428-1437

    • DOI

      10.1038/mp.2014.153

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exercise-induced neuronal effects and the 5-HT3 receptor.2015

    • Author(s)
      Makoto Kondo(*Corresponding author), Shoichi Shimada.
    • Journal Title

      Neurotransmitter

      Volume: 2

    • DOI

      10.14800/nt.764

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serotonin and exercise-induced brain plasticity.2015

    • Author(s)
      Makoto Kondo(*Corresponding author), Shoichi Shimada.
    • Journal Title

      Neurotransmitter

      Volume: 2

    • DOI

      10.14800/nt.793

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 環境や経験依存的な脳可塑性の分子メカニズムに関する研究2015

    • Author(s)
      近藤誠
    • Journal Title

      神経化学

      Volume: 54 Pages: 60-62

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus.2015

    • Author(s)
      Maehara T; Matsumoto K; Horiguchi K; Kondo M; Iino S; Horie S; Murata T; Tsubone H; Shimada S; Ozaki H; Hori M.
    • Journal Title

      Br J Pharmacol

      Volume: 172(4) Issue: 4 Pages: 1136-1147

    • DOI

      10.1111/bph.13006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 5-hydroxytryptamine type-3A receptor in the process of fear extinction.2014

    • Author(s)
      Kondo M. (*Corresponding author) and Shimada S.
    • Journal Title

      Receptors & Clinical Investigation

      Volume: 1 Pages: 33-37

    • DOI

      10.14800/rci.71

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5-HT3 receptor expression in the mouse vestibular ganglion2014

    • Author(s)
      Takimoto Y, Ishida Y, Nakamura Y, Kamakura T, Yamada T, Kondo M, Kitahara T, Uno A, Imai T, Horii A, Okazaki S, Nishiike S, Inohara H, Shimada S
    • Journal Title

      Brain Res

      Volume: 1557 Pages: 74-82

    • DOI

      10.1016/j.brainres.2014.02.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination of bladder ultrasonography and novel cystometry method in mice reveals rapid decrease of bladder capacity and compliance in LPS-induced cystitis.2014

    • Author(s)
      Kentaro Takezawa, Makoto Kondo(*Corresponding author), Hiroshi Kiuchi, Tetsuji Soda, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, and Shoichi Shimada.
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 307 Issue: 2 Pages: F234-F241

    • DOI

      10.1152/ajprenal.00043.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The 5-HT3A receptor is essential for fear extinction.2013

    • Author(s)
      Kondo M, Nakamura Y, Ishida Y, Yamada T, Shimada S
    • Journal Title

      Learn Mem

      Volume: 21 Issue: 1 Pages: 1-4

    • DOI

      10.1101/lm.032193.113

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Roles of serotonergic system in hippocampal neurogenesis.2016

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 環境や経験依存的な脳の形態的・機能的可塑性の分子機序に関する研究2016

    • Author(s)
      近藤誠
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 5-HT3受容体を介した新しい膀胱知覚亢進メカニズム2015

    • Author(s)
      竹澤健太郎、近藤誠、島田昌一
    • Organizer
      第91回日本解剖学会近畿支部学術集会
    • Place of Presentation
      京都工芸繊維大学総合研究棟
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      近藤誠
    • Organizer
      第11回成体脳のニューロン新生懇談会
    • Place of Presentation
      名古屋市立大学大学院医学系研究科研究棟
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Organizer
      Society for Neuroscience 45th Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動による抗うつ効果の分子メカニズム2015

    • Author(s)
      近藤誠
    • Organizer
      最先端医療イノベーションセンター定例セミナー 第3回
    • Place of Presentation
      大阪大学最先端医療イノベーションセンター
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      近藤誠
    • Organizer
      第5回若手研究フォーラム
    • Place of Presentation
      大阪大学 銀杏会館
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      埼玉県さいたま市、大宮ソニックシティ
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膀胱ATPシグナル伝達の生理的・病的意義の検討2015

    • Author(s)
      竹澤健太郎、上田倫央、惣田哲次、福原慎一郎、木内寛、宮川康、高尾徹也、辻村晃、根来宏光、松本―宮井和政、近藤誠、島田昌一、野々村祝夫
    • Organizer
      第22回日本排尿機能学会
    • Place of Presentation
      京王プラザホテル札幌
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動が抗うつ効果をもたらす機序の解析2015

    • Author(s)
      近藤誠
    • Organizer
      第17回ORIGIN神経科学研究会
    • Place of Presentation
      下関市豊北生涯学習センター
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝子改変マウスを用いた膀胱機能研究2015

    • Author(s)
      竹澤健太郎、近藤誠、島田昌一
    • Organizer
      第17回ORIGIN神経科学研究会
    • Place of Presentation
      下関市豊北生涯学習センター
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動による抗うつ効果のメカニズム2015

    • Author(s)
      近藤誠
    • Organizer
      第4回大阪大学神経難病フォーラム
    • Place of Presentation
      大阪大学最先端医療イノベーションセンター
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] A novel mechanism of infection-induced bladder hyperactivity: Lipopolysaccharide causes rapid ATP release from urothelium and stimulates the mechanosensory afferent pathway2015

    • Author(s)
      Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Shinichiro Fukuhara, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Kazumasa Matsumoto-Miyai, Shoichi Shimada and Norio Nonomura.
    • Organizer
      American Urological Association (AUA) Annual Meeting 2015
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細菌性膀胱炎における膀胱知覚亢進の新機構-LPSは炎症とは独立して膀胱上皮のATP放出を惹起しP2X受容体を介してmechanosensitive afferentを活性化する2015

    • Author(s)
      竹澤健太郎、惣田哲次、福原慎一郎、木内寛、高尾徹也、宮川康、辻村晃、近藤誠、松本―宮井和政、島田昌一、野々村祝夫
    • Organizer
      第103回日本泌尿器科学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The 5-HT3 receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects.2015

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada.
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Examination of the change of IDO2 expression in the mouse under inflammatory condition.2015

    • Author(s)
      Yusuke Ishida, Yukiko Yamamoto, Makoto Kondo, Takuya Magome, Shoichi Shimada.
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 5-HT3 receptor expression in the mouse vestibular ganglion.2015

    • Author(s)
      Yasumitsu Takimoto, Yusuke Ishida, Yukiko Nakomura, Takefumi Kamakura, Makoto Kondo.
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel mechanism of infection-induced bladder hyperactivity: LPS causes rapid urothelial ATP release and stimulates the mechanosensory afferent pathway2015

    • Author(s)
      Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura and Shoichi Shimada.
    • Organizer
      The Annual European Association of Urology (EAU) Congress
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2015-03-20 – 2015-03-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 海馬神経新生におけるセロトニン神経系の役割の解明2015

    • Author(s)
      近藤誠
    • Organizer
      第4回若手研究フォーラム
    • Place of Presentation
      大阪大学医学部
    • Year and Date
      2015-02-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動による海馬神経新生の増大や抗うつ効果には5-HT3受容体が必須である2014

    • Author(s)
      近藤誠、島田昌一
    • Organizer
      第90回日本解剖学会近畿支部学術集会
    • Place of Presentation
      大阪大学医学部保健学科
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] A novel cystometry method combined with bladder ultrasonography reveals rapid decrease of bladder capacity and compliance in mice LPS-induced cystitis2014

    • Author(s)
      Kentaro Takezawa, Makoto Kondo, Hiroshi Kiuchi, Tetsuji Soda, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura and Shoichi Shimada.
    • Organizer
      International Continence Society Annual Meetings
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Year and Date
      2014-10-20 – 2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] セロトニン3A受容体は恐怖記憶の消去に必須である2014

    • Author(s)
      近藤誠、中村雪子、石田雄介、島田昌一
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良県文化会館・奈良県新公会堂
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスにおける炎症時のIDOの発現の変化の検討2014

    • Author(s)
      石田雄介、中村雪子、近藤誠、島田昌一
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良県文化会館・奈良県新公会堂
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスビデオウロダイナミクスの開発2014

    • Author(s)
      竹澤健太郎、惣田哲次、福原慎一郎、木内寛、高尾徹也、宮川康、辻村晃、野々村祝夫、近藤誠、島田昌一
    • Organizer
      第21回日本排尿機能学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] The 5-HT3A receptor is essential for fear extinction2014

    • Author(s)
      Makoto Kondo, Yukiko Nakamura, Yusuke Ishida, Shoichi Shimada
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Examination of the change of IDO expression in the mouse brain under inflammatory condition2014

    • Author(s)
      Yusuke Ishida, Yukiko Nakamura, Makoto Kondo, Shoichi Shimada
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 海馬における5-HT3受容体の役割2014

    • Author(s)
      近藤誠
    • Organizer
      第16回ORIGIN神経科学研究会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2014-08-31 – 2014-09-01
    • Related Report
      2014 Research-status Report
  • [Book] ブレインサイエンス・レビュー20162016

    • Author(s)
      近藤誠
    • Publisher
      株式会社 クバプロ
    • Related Report
      2015 Annual Research Report
  • [Remarks] 運動がうつ病予防・改善に役立つメカニズムを解明 こころの健康を目指して

    • URL

      http://resou.osaka-u.ac.jp/ja/research/2014/20141118_1

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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