Development of the noninvasive screening system which aimed at the schizophrenia prophylaxis
Project/Area Number |
26860927
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Shimane University |
Principal Investigator |
Wake Rei 島根大学, 人間科学部, 准教授 (60609262)
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Co-Investigator(Renkei-kenkyūsha) |
Oh-Nishi Arata 島根大学, 医学部, 特任教授 (00507014)
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Research Collaborator |
Inagaki Takuji
Hasegawa Yuki
Araki Tomoko
Tsuchie Keiko
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 統合失調症 / 発症危険状態 / 児童思春期 / バイオピリン / コルチゾール / 精神病前駆状態 / 早期介入 / スクリーニング / 児童 / 生物学的マーカー / 自律神経機能 / 脳機能イメージング / schizophrenia / Schizophrenia |
Outline of Final Research Achievements |
The early risk diagnosis of present schizophrenia is a diagnosis mainly composed of structured interviews, and development of the biomarkers based on scientific grounds is an urgent problem. For children and adlescents at risk mental state (ARMS), we measured an oxidative stress state using "biomarker urinary and in saliva".The urinary stress markers were significantly expensive in ARMS group.The likelihood that we could screen for an objective index about the prodromal early diagnosis of schizophrenia using several stress biomarkers such as urinary cortisol and biopyrrin level was suggested.
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Academic Significance and Societal Importance of the Research Achievements |
統合失調症は極めて重篤な精神神経疾患である。未治療期間の長期化は、その治療予後悪化に多大な影響を及ぼすため、早期診断、早期介入がきわめて重要である。しかし、現状の統合失調症の早期リスク診断は構造化面接を主体とした診断であり、科学的根拠に基づいたバイオマーカーの開発が喫緊の課題である。 本研究では、統合失調症ハイリスク児童において、尿中バイオピリンが優位に上昇し、尿中κおよびλFLCが優位に減少しており、この2つの組み合わせがバイオマーカーとなりうることを報告した。この結果から、今後、早期のリスク判定ができる発症予防介入システムを確立し、早期介入から精神病発症予防や治療予後の改善を期待できる。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Epidemiological Characteristics of Disaster-related Suicides in the 3-4 Years since the Great East Japan Earthquake.2016
Author(s)
Inoue K, Takeshita H, Takinami Y, Hoshi M, Noso Y, Takeichi N, Fujihara J, Kimura-Kataoka K, Fujita Y, Wake R, Miyaoka T, Ezoe S, Horiguchi J, Okazaki Y
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Journal Title
International Journal of Emergency Mental Health and Human Resilience
Volume: 18(2)
Pages: 742-743
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy and Safety of Sansoninto in Insomnia with Psychiatric Disorder: An Open-Label Study.2015
Author(s)
Tsuyoshi Miyaoka, Kiminori Kawano, Motohide Furuya, Rei Wake, Sadayuki Hashioka, Kristian Liaury, Erlyn Limoa, Keiko Tsuchie, Michiyo Fukushima, Tomoko Araki, Jun Horiguchi
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Journal Title
Journal Alternative & Integrative Medicine
Volume: 4(1)
Issue: 01
Pages: 6-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy and safety of yokukansan in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled trial (a Positive and Negative Syndrome Scale, five-factor analysis).2015
Author(s)
Tsuyoshi Miyaoka, Motohide Furuya, Jun Horiguchi, Rei Wake, Sadayuki Hashioka, Masaya Tohyama, Norio Mori, Yoshio Minabe, Masaomi Iyo, Shyuichi Ueno, Sachiko Ezoe, Kenta Murotani, Syuzo Hoshino, Haruo Seno
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Journal Title
Psychopharmacology
Volume: 232(1)
Pages: 155-164
Related Report
Open Access / Acknowledgement Compliant
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[Journal Article] The effects of combine treatment of memantine and donepezil on Alzheimer's disease patients and its relationship with cerebral blood flow in the prefrontal area.2014
Author(s)
Araki T, Wake R, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Liaury K, Hashioka S, Murotani K, Horiguchi J
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Journal Title
Int J Geriatr Psychiatry
Volume: 29(9)
Pages: 881-889
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and improved schizophrenia-like behavior of Gunn Rat.2016
Author(s)
LIMOA ERLYN, 橋岡禎征, 宮岡剛, 土江景子, 荒内亮輔, ABDUL AZIS ILHAMUDDIN, 和氣玲, 林田麻衣子, 荒木智子, 古屋智英, LIAURY KRISTIAN, TANRA ANDI JAYALANGKARA, 堀口淳
Organizer
Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and improved schizophrenia-like behavior of Gunn Rat.
Place of Presentation
松山市(メルパルク松山)
Year and Date
2016-11-10
Related Report
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[Presentation] 意欲低下に対して釣藤散が有用と思われた軽度認知障害の1症例.2016
Author(s)
長濱道治, 小池昌弘, 松田泰行, 三木啓之, 田中一平, 三浦章子, 金山三紗子, 山下智子, 河野公範, 林田麻衣子, 岡崎四方, 和氣玲, 橋岡禎征, 宮岡剛, 堀口淳
Organizer
第31回日本老年精神医学会.
Place of Presentation
金沢市(金沢歌劇座)
Year and Date
2016-06-23
Related Report
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