Socia deficits and prefrontal activation in autism spectrum disorders; neuroimaging and genetics study.

Research Project

Project/Area Number	26860929
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Hiroshima University
Principal Investigator	Kajiume Aiko 広島大学, 大学病院, 医科診療医 (00448250)
Research Collaborator	KAWAMOTO Akiko
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	イメージングジェネティクス / 自閉症スペクトラム / 前頭葉機能
Outline of Final Research Achievements	We conducted a NIRS study to explore social dysfunction in children with autism spectrum disorder during facial expression task. Furthermore, we explored gene polymorphisms in ASD and relationship between gene polymorphisms and brain activations. The oxygenated hemoglobin concentration changes during facial expression task were significantly smaller in the ASD group than in the control group. Gene polymorphisms were not related to brain activations. We intend to continue this study with larger participants.