Genome-wide association study of plasma total homocysteine in schizophrenia

Research Project

Project/Area Number	26860931
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	The University of Tokushima
Principal Investigator	KINOSHITA Makoto 徳島大学, 大学病院, 特任助教 (40622478)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	統合失調症 / ホモシステイン / ゲノムワイド遺伝子関連解析 / 遺伝子多型
Outline of Final Research Achievements	Homocysteine is a sulfur amino acid and a key substance in the methionine cycle.Previous meta-analyses of association studies between blood homocysteine and schizophrenia have demonstrated an elevated blood homocysteine level in schizophrenia.We conducted a genome-wide association study in 384 patients with schizophrenia.We found novel associations of 3 SNPs with the plasma total homocysteine levels.This is the first genome-wide association study of the plasma total homocysteine in patients with schizophrenia.

Report

(3 results)