Identification of micro-endophenotype of schizophrenia using human induced-neuronal (iN) cells

Research Project

Project/Area Number	26860932
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Kyushu University
Principal Investigator	Sagata Noriaki 九州大学, 医学研究院, 学術研究員 (00632308)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	統合失調症 / iN細胞 / トランスレーショナル研究 / 直接誘導神経細胞 / 精神疾患
Outline of Final Research Achievements	Induced-neuronal (iN) cells have attracted attention in that live human neuronal cells that are analyzable in a very short period can be obtained compared to iPS-derived neurons. There was a disadvantage on the efficiency of generating iN cells with using adult-derived fibroblasts. We successfully established a method of iN cell creation from a wide range of age regardless of age by devising the induction and culture conditions of this iN cell. By comparing iN cells derived from adult schizophrenia patients and healthy controls, we found a gene whose mRNA expression level is about 2-fold increased specifically in neurons of schizophrenic patients.