Establishment of humani microglial cells and application to psychiatric disorders

• Project/Area Number: 26860933
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Ohgidani Masahiro 九州大学, 医学研究院, 学術研究員 (60636455)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ミクログリア / iMG

Outline of Final Research Achievements

・It was succeeded that establishment of human microglia-like cells from monocyte.
・Abnormality of microglial function was observed in microglilal disease including psychiatric disorders.
・It was suggested that this technique will be useful for future microglial studies.

Research Products

• [Journal Article] Microglial CD206Gene Has Potential as a State Marker of Bipolar Disorder (2017)
  • Author(s): M. Ohgidani, T.A. Kato, Y. Haraguchi, T. Matsushima, Y. Mizoguchi, T. Murakawa-Hirachi, N. Sagata, A. Monji, S. Kanba
  • Journal Title: Frontiers in Immunology Volume: 7 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders (2015)
  • Author(s): Ohgidani M, Kato TA*, Kanba S.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: in press Pages: 184-184
  • DOI: 10.3389/fncel.2015.00184
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease. (2014)
  • Author(s): Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 4957-4957
  • DOI: 10.1038/srep04957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Psychiatric translational research using human blood-induced microglial (iMG) cells (2017)
  • Author(s): M. Ohgidani, T.A. Kato, S. Kanba
  • Organizer: 5th AsCNP
  • Place of Presentation: インドネシア、バリ
  • Int'l Joint Research / Invited
• [Presentation] Translational research of chronic pain patients using human blood-induced microglia-like (iMG) cells (2015)
  • Author(s): Ohgidani M, Kato TA, Hosoi M, Tsuda M, Hayakarwa K, Sudo N, Kanba S
  • Organizer: The 58th Annual meeting of the japanese society for neurochemistry
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2015-09-12
• [Presentation] Modeling brain diseases with direct induction technology of ramified microglia-like (iMG) cells from human monocytes (2014)
  • Author(s): Ohgidani, M. Kato, T. A. Kanba, S.
  • Organizer: 12th International Congress of Neuroimmunology (ISNI)
  • Place of Presentation: Mainz, GERMANY
  • Year and Date: 2014-11-09 – 2014-11-13
• [Presentation] Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease (2014)
  • Author(s): Ohgidani M, Kato TA, Kanba S
  • Organizer: Shared Pathways to Novel Treatment Strategies Beyond Boundaries in Psychiatry and Neurology
  • Place of Presentation: Munich, GERMANY
  • Year and Date: 2014-06-29 – 2014-07-04