| Project/Area Number |
26860934
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
Oda Yuko 九州大学, 医学(系)研究科(研究院), 特別教員 (70721265)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Toshihiko 九州大学, 医学研究院, 助教 (40448436)
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| Co-Investigator(Renkei-kenkyūsha) |
TOBIMATSU Shozo 九州大学, 医学研究院, 教授 (40164008)
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| Research Collaborator |
HIRONAGA Masato
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | bipolar disorder / ASSR / MEG / MRI / binaural / monaural / 双極性障害 / 脳磁図 / 片耳刺激 / 聴覚刺激 |
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| Outline of Final Research Achievements |
In a current status of clinical psychiatry, Therefore, the patients with bipolar disorder (BD) are often misdiagnosed and cannot receive the adequate treatment. This is probably due to the facts that the biological pathology of BD is unrevealed and the diagnostic method and treatment marker are not well developed. Neural circuitry restricted to the primary auditory cortex can be assessed using magnetoencephalography (MEG) - auditory steady-state response (ASSR). In binaural ASSR, a region of interest was marked in supratemporal gyrus. The strong power and increased phase-locking factors (PLFs) in time-frequency domain were robustly observed in normal controls while those of BDs were unremarkable. In monaural ASSR, the results of the PLFs in BDs were considered to be stable with continuation in the right hemisphere. MEG is an equipment that is non-invasive for patients. We will continue to apply ASSR to BD for determining the objective biomarker of BD.
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