| Project/Area Number |
26860937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老年精神医学 / レビー小体型認知症 / レム睡眠行動障害 / レビー小帯型認知症 / バイオマーカー / Dat Scan |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate the extent with which diagnostic accuracy can be increased using a combination of brain perfusion SPECT (bp-SPECT), MIBG scintigraphy, and DAT-SPECT. Thirty-four patients with probable DLB (75.0 ± 8.3 years old, 14 male: 20 female) underwent bp-SPECT, MIBG myocardial scintigraphy, and DAT-SPECT. Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) or DAT-SPECT (79%) had better sensitivity for characteristic abnormalities in DLB than bp-SPECT (50%). The combination of the three modalities could increase sensitivity for diagnosis of DLB to 100%. We also performed the subanalysis about the sensitivity of three modalities in DLB patients with REM sleep behavior disorder (RBD). The sensitivity of bp-SPECT, MIBG scintigraphy, and DAT-SPECT was 58.6%, 100%, and 96.6%, respectively. Even stand-alone diagnostic means had high sensitivity in DLB with RBD.
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