The application of diagnosis and treatment for REM sleep behavior disorder in dementia with Lewy bodies

• Project/Area Number: 26860937
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: KOBAYASHI SEIIJU 札幌医科大学, 医学部, 講師 (50569035)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 老年精神医学 / レビー小体型認知症 / レム睡眠行動障害 / レビー小帯型認知症 / バイオマーカー / Dat Scan

Outline of Final Research Achievements

The aim of this study was to evaluate the extent with which diagnostic accuracy can be increased using a combination of brain perfusion SPECT (bp-SPECT), MIBG scintigraphy, and DAT-SPECT. Thirty-four patients with probable DLB (75.0 ± 8.3 years old, 14 male: 20 female) underwent bp-SPECT, MIBG myocardial scintigraphy, and DAT-SPECT. Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) or DAT-SPECT (79%) had better sensitivity for characteristic abnormalities in DLB than bp-SPECT (50%). The combination of the three modalities could increase sensitivity for diagnosis of DLB to 100%. We also performed the subanalysis about the sensitivity of three modalities in DLB patients with REM sleep behavior disorder (RBD). The sensitivity of bp-SPECT, MIBG scintigraphy, and DAT-SPECT was 58.6%, 100%, and 96.6%, respectively. Even stand-alone diagnostic means had high sensitivity in DLB with RBD.

Research Products

• [Presentation] 認知症における性差の影響 (2016)
  • Author(s): 小林清樹
  • Organizer: 第９回日本性差医学会
  • Place of Presentation: 札幌
  • Year and Date: 2016-01-30
  • Invited
• [Presentation] The usefulness of a blood flow analyzing program eZIS in the differential diagnosis between idiopathic Normal Pressure Hydrocephalus and Alzheimer’s disease. (2015)
  • Author(s): Seiju Kobayashi, Masaru Tateno, Kumiko Utsumi, Tomo Iwamoto, Hidetoshi Morii, Chiaki Kawanishi
  • Organizer: Alzheimer’s Disease International (ADI) 2015
  • Place of Presentation: manilla
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] A community network to support people with dementia. (2015)
  • Author(s): Seiju Kobayashi , Masaru Tateno , Tomo Iwamoto, Kumiko Utsumi , Chiaki Kawanishi
  • Organizer: 12th World Congress of the World Association for Psychosocial Rehabilitation
  • Place of Presentation: Seoul
  • Year and Date: 2015-11-02
  • Int'l Joint Research
• [Presentation] The effect of Apolipoprotein E ε4 allele on the morphological and functional neuroimaging in late onset Alzheimer’s disease. (2015)
  • Author(s): Seiju Kobayashi
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: Honolulu (America)
  • Year and Date: 2015-09-02 – 2015-09-05
• [Presentation] The effect of Apolipoprotein E ε4 allele on the morphological and functional neuroimaging in late onset (2015)
  • Author(s): Seiju Kobayashi , Masaru Tateno, Kumiko Utsumi , Hitoshi Sohma, Yasuo Kokai, Yoichi M. Ito,Hidetoshi Morii, Chiaki Kawanishi
  • Organizer: World Molecular Imaging Congress 2015
  • Place of Presentation: Honolulu
  • Year and Date: 2015-09-01
  • Int'l Joint Research
• [Presentation] A long-term care community network to support people with dementia. (2015)
  • Author(s): Seiju Kobayashi
  • Organizer: WPA Regional Congress
  • Place of Presentation: Osaka International Convention Center(Osaka)
  • Year and Date: 2015-06-04 – 2015-06-06
• [Presentation] A long-term care community network to support people with dementia. (2015)
  • Author(s): Kobayashi S(他4名1番目)
  • Organizer: WPA regional congress, 2015
  • Place of Presentation: Osaka
  • Year and Date: 2015-06-04
  • Int'l Joint Research / Invited
• [Presentation] Amelioration of treatment-reflactory depression with intravenous stem cells. (2015)
  • Author(s): Ukai W, Kobayashi S(他8名9番目)
  • Organizer: The International College of Neuropsychopharmacolofy Tehmatic Meeting on Stress, in-flammation and depression: focus on novel antidepressant targets: 2015
  • Place of Presentation: Dublin
  • Year and Date: 2015-06-04
  • Int'l Joint Research / Invited
• [Presentation] Stem cell therapy: a regenerative approach for refractory psychiatric diseases. (2015)
  • Author(s): ３．Ukai W, Furuse K, Kigawa Y, Tsujino H, Ishii T, Tayama M, Iwamoto T, Shiraishi M, Inoue K, Kobayashi S, Hashimoto E, Kawanishi C
  • Organizer: Alcohol and Disease: Mechanism and Control. In: Korean Society for Biochemistry and Mo-lecular Biology (KSBMB): 2015
  • Place of Presentation: Seoul
  • Year and Date: 2015-05-12
  • Int'l Joint Research / Invited
• [Presentation] 神経梅毒として加療を行った一症例の検討 (2014)
  • Author(s): 小林 清樹
  • Organizer: 日本高次脳機能障害学会
  • Place of Presentation: 仙台国際センター（宮城県、仙台市）
  • Year and Date: 2014-11-28 – 2014-11-29