The relationships between treatment resistant psychiatric patients and anti NMDA receptor antibodies
| Project/Area Number |
26860938
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
CHIBA Yuhei 横浜市立大学, 医学研究科, 客員研究員 (50722500)
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| Research Collaborator |
HIAYASU Yoshio
KATSUSE Omi
FUJISHIRO Hiroshige
KAMADA Ayuko
SUDA Akira
SAITO Tomoyuki
IKURA Takahiro
HATTORI Saki
ABE Kie
TOYOHARA Nao
YAMAGUCHI Hiroyuki
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 精神免疫学 / 脳器質性精神疾患 / 辺縁系脳炎 / 自己免疫性脳炎 / NMDA受容体脳炎 / 橋本脳症 / 自己免疫脳炎 / 自己抗体 / 難治性精神疾患 / NMDA受容体 / 器質性精神疾患 / 自己免疫性精神疾患 |
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| Outline of Final Research Achievements |
I investigated the clinical characteristics of the treatment-resistant psychiatric patients with anti NMDA receptor antibodies to reveal the pathological association between anti NMDA receptor antibodies and psychiatric symptoms or cognitive impairments. I reported the case series of patients responded to the steroid pulse therapy and the case series with features of Lewy body dementias. I also reported the relationships between anti NMDA receptor antibodies and cognitive impairment in the treatment-resistant psychiatric patients. This will open the new treatment strategy for the psychiatric patients with autoimmune disturbance.
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Report
(5 results)
Research Products
(20 results)
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[Presentation] Evaluation of titers of antibodies against peptides of subunit(NR1,NR2B) of glutamate receptor with enzyme-linked immunosorbent assaystudies in psychiatric patients with anti-thyroid antibodies.2015
Author(s)
Takahiro Ikura, Omi Katsuse, Yuhei Chiba, Yukitoshi Takahashi, Hiroshige Fujishiro, Mituhiro Takeno, Maasa Hama, Ayuko Kamada, Tomoyuki Saito, Yoshio Hirayasu
Organizer
WPA Regional Congress OSAKA Japan 2015
Place of Presentation
大阪国際会議場（Osaka）
Year and Date
2015-06-04
Related Report
Int'l Joint Research
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