Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
The pathobiology of schizophrenia is still unclear despite its high lifetime prevalence about 1%. There exist methodological limitations under the difficulty such as inaccessibility of the live brain. However, a technology of induced pluripotent stem cells (iPSCs) allows us to investigate living human brain cells. Here, we present our studies using iPSCs-derived neurons of discordant schizophrenia and the healthy controls. As a result, impaired synapse formation was observed in iPSCs-derived neurons of schizophrenia patient.
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