Analysis of induced pluripotent stem cell derived-neurons of patients with schizophrenia in vitro and in vivo
Project/Area Number |
26860940
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Nara Medical University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 統合失調症 / iPS細胞 / シナプス / 細胞培養 / 培養系 |
Outline of Final Research Achievements |
The pathobiology of schizophrenia is still unclear despite its high lifetime prevalence about 1%. There exist methodological limitations under the difficulty such as inaccessibility of the live brain. However, a technology of induced pluripotent stem cells (iPSCs) allows us to investigate living human brain cells. Here, we present our studies using iPSCs-derived neurons of discordant schizophrenia and the healthy controls. As a result, impaired synapse formation was observed in iPSCs-derived neurons of schizophrenia patient.
|
Report
(3 results)
Research Products
(1 results)