Analysis of induced pluripotent stem cell derived-neurons of patients with schizophrenia in vitro and in vivo

Research Project

Project/Area Number	26860940
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Nara Medical University
Principal Investigator	Toritsuka Michihiro 奈良県立医科大学, 医学部, 助教 (20588529)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	統合失調症 / iPS細胞 / シナプス / 細胞培養 / 培養系
Outline of Final Research Achievements	The pathobiology of schizophrenia is still unclear despite its high lifetime prevalence about 1%. There exist methodological limitations under the difficulty such as inaccessibility of the live brain. However, a technology of induced pluripotent stem cells (iPSCs) allows us to investigate living human brain cells. Here, we present our studies using iPSCs-derived neurons of discordant schizophrenia and the healthy controls. As a result, impaired synapse formation was observed in iPSCs-derived neurons of schizophrenia patient.