Association of cognitive impairment with acetylcholine and GABA/glutamatergic function in schizophrenia
| Project/Area Number |
26860941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Takahashi Shun 和歌山県立医科大学, 医学部, 講師 (10508021)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 統合失調症 / 認知機能障害 / アセチルコリン機能 / GABA/グルタミン酸機能 / 経頭蓋磁気刺激 / 認知機能 / 皮質興奮性 |
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| Outline of Final Research Achievements |
The aim of this study was examining association of cognitive impairment with acetylcholine and GABA/glutamatergic function in schizophrenia using transcranial magnetic stimulation (TMS). In assessment of GABA/glutamatergic function using paired pulse TMS (ppTMS), cortical excitability was increased in schizophrenia and it related to cognitive impairment and duration of illness. In assessment of acetylcholine function, we developed effortless measuring system of short latency afferent inhibition (SAI) using TMS and median nerve electrical stimulation, and corrected normal control data in this research period.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Microstructural abnormalities in anterior callosal fibers and their relationship with cognitive function in major depressive disorder and bipolar disorder: A tract-specific analysis study2015
Author(s)
Yamada S, Takahashi S, Ukai S, Tsuji T, Iwatani J, Tsuda K, Kita A, Sakamoto Y, Yamamoto M, Terada M, Shinosaki K
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Journal Title
Journal of Affective Disorders
Volume: 174
Pages: 542-548
DOI
Related Report
Peer Reviewed
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