| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We performed in vivo dopamine D2 receptor occupancy analysis during continuous antipsychotic treatment (haloperidol or olanzapine), and developed the clinically-relevant antipsychotic dose regimen in mice. We observed working memory in chronic saline- and phencyclidine-treated mice, and they showed reduced correct responses in the working memory task, suggesting impaired working memory. We also identified brain regions relevant to working memory impairments in this mouse model. Our results may lead to the identification of novel therapeutic targets for patients with schizophrenia.
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