Exploration of novel targets for treating schizophrenia
| Project/Area Number |
26860942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
Arime Yosefu 獨協医科大学, 医学部, 助教 (80609404)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 統合失調症 / モデルマウス / 抗精神病薬 / 受容体占有率 / 行動 / ワーキングメモリー / 動物モデル / 前辺縁皮質 / プロテオミクス |
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| Outline of Final Research Achievements |
We performed in vivo dopamine D2 receptor occupancy analysis during continuous antipsychotic treatment (haloperidol or olanzapine), and developed the clinically-relevant antipsychotic dose regimen in mice. We observed working memory in chronic saline- and phencyclidine-treated mice, and they showed reduced correct responses in the working memory task, suggesting impaired working memory. We also identified brain regions relevant to working memory impairments in this mouse model. Our results may lead to the identification of novel therapeutic targets for patients with schizophrenia.
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Report
(4 results)
Research Products
(9 results)
