An exploratory study of the neural networks related to the effect of mood stabilizers on antidepressant-induced mania
Project/Area Number |
26860943
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Dokkyo Medical University |
Principal Investigator |
KURATOMI GO 獨協医科大学, 医学部, 助教 (00593592)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 双極性障害 / うつ病 / 気分障害 / 抗うつ薬 |
Outline of Final Research Achievements |
Antidepressant-induced mania and aggressive behavior during the pharmacologic treatment of mood disorders are severe problems that affect patient’s interpersonal relationships. For the purpose of analyzing pathological mechanisms of antidepressant-induced mania, we conducted behavioral analysis of mutant mitochondrial DNA polymerase gamma 1 transgenic (Tg) mice, which was reported to show mood disorder-like phenotypes, during continuous treatment with antidepressant imipramine. We revealed that Tg mice displayed abnormalities of social behaviors and the activity rhythm. Tg mice also showed high agonistic behavior in the early phase of imipramine treatment. We also demonstrate imipramine treatment lowered the dominance hierarchy of Tg mice, which was not prevented by treatment with low-dose lithium.
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Report
(4 results)
Research Products
(3 results)