| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Antidepressant-induced mania and aggressive behavior during the pharmacologic treatment of mood disorders are severe problems that affect patient’s interpersonal relationships. For the purpose of analyzing pathological mechanisms of antidepressant-induced mania, we conducted behavioral analysis of mutant mitochondrial DNA polymerase gamma 1 transgenic (Tg) mice, which was reported to show mood disorder-like phenotypes, during continuous treatment with antidepressant imipramine. We revealed that Tg mice displayed abnormalities of social behaviors and the activity rhythm. Tg mice also showed high agonistic behavior in the early phase of imipramine treatment. We also demonstrate imipramine treatment lowered the dominance hierarchy of Tg mice, which was not prevented by treatment with low-dose lithium.
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