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Investigating the optimization for using translated Direct Current Stimulation in patients with depression.

Research Project

Project/Area Number 26860950
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKansai Medical University

Principal Investigator

NISHIDA Keiichiro  関西医科大学, 医学部, 講師 (40567567)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordstDCS / 経頭蓋直流刺激 / うつ病 / 内側前頭前野 / 左背外側前頭前野 / tDCS / 不安 / PANAS / LORETA / EEG / 脳波 / WCST / 電気刺激 / 経頭蓋直流電気刺激法 / ニューロモジュレーション / microstate
Outline of Final Research Achievements

We found lDLPFC stimulation significantly decreased negative affect in the depressive patients, compared with mPFC stimulation.
Next, we examined the relationship between resting EEG before tDCS and changes in anxiety before and after tDCS. The current densities in the region of interests were calculated in healthy volunteers before F5 site stimulation by tDCS. The changing of state-Trait Anxiety Inventory which is the evaluation scale of anxiety, could be predicted by the current density at the lower left temporal region in the beta 2 band.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] 「うつ病におけるtDCS (経頭蓋直流電気刺激)の効果」2016

    • Author(s)
      西田圭一郎
    • Journal Title

      最新精神医学

      Volume: 21 Pages: 111-116

    • Related Report
      2016 Research-status Report
  • [Journal Article] Discovering EEG resting state alterations of semantic dementia.2016

    • Author(s)
      1.Grieder M, Koenig T, Kinoshita T, Utsunomiya K, Wahlund LO, Dierks T, Nishida K
    • Journal Title

      Clinical neurophysiology

      Volume: 127 Issue: 5 Pages: 2175-2181

    • DOI

      10.1016/j.clinph.2016.01.025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] うつ病におけるtDCS(経頭蓋直流電気刺激)の 効果2016

    • Author(s)
      西田圭一郎ら
    • Journal Title

      最新精神医学

      Volume: 21 Pages: 111-116

    • Related Report
      2015 Research-status Report
  • [Journal Article] Integrating Different Aspects of Resting Brain Activity: A Review of Electroencephalographic Signatures in Resting State Networks Derived from Functional Magnetic Resonance Imaging2015

    • Author(s)
      Keiichiro Nishida, Nadja Razavi, Kay Jann, Masafumi Yoshimura, Thomas Dierks, Toshihiko Kinoshita, Thomas Koenig
    • Journal Title

      Neuropsychobiology

      Volume: 7 Issue: 1 Pages: 6-16

    • DOI

      10.1159/000363342

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 精神疾患における tDCS(transcranial direct current stimulation)の効果 - うつ病を中心に -2016

    • Author(s)
      西田圭一郎
    • Organizer
      第46回日本臨床神経生理学会
    • Place of Presentation
      ホテルハマツ(福島)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] transcranial direct current stimulation(tDCS) による脳電場構造の変化とその効果2015

    • Author(s)
      西田圭一郎
    • Organizer
      第45 回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Aberrant functional networks in AD patients:LORETA directional transmission2015

    • Author(s)
      Keiichiro Nishida, Roberto Pascual-Marqui, Masafumi Yoshimura, Yuichi Kitaura, Hiroshi Mii, Toshiaki Isotani, Toshihiko Kinoshita
    • Organizer
      Annual Conference Joint Meeting of ECNS, ISNIP and ISBET 2015
    • Place of Presentation
      ミュンヘン・ドイツ
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2019-03-29  

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