| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we generated Ant1 conditional knockout (cKO) mice to investigate the relationship between mitochondrial function and bipolar disorder like phenotype manifestation. As a result, we found that Ant1 cKO mice showed behavioral phenotype indicating suppression of impulsivity, especially cognitive impulsivity rather than motor impulsivity. In addition, Ant1 cKO mice showed promotion of serotonin and dopamine metabolism in the nucleus accumbens. These results suggest that mitochondrial function in brains has important roles in regulation of monoamines which act as neurotransmitters and in judgment of the reward value. These molecular mechanisms may be one of causes of bipolar disorder onset.
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