| Project/Area Number |
26860967
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Southen Tohoku Research Institute for Neuroscience (2015)
Hirosaki University (2014) |
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Principal Investigator |
Hirose Katsumi 一般財団法人脳神経疾患研究所, その他部局等, その他 (60623767)
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| Research Collaborator |
TAKAI Yoshihiro 一般財団法人 脳神経疾患研究所, 南東北BNCT研究センター, センター長
SATO Mariko 弘前大学, 大学院医学研究科, 助教
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌幹細胞 / CD133 / 低酸素 / 放射線増感 / マイクロカプセル / 定位放射線治療 / 低酸素細胞 |
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| Outline of Final Research Achievements |
Radioresistance in human cancer has been linked in part to a subset of cells termed cancer stem cells (CSCs). The prominin 1 (CD133) cell surface protein is proposed to be a marker enriching for CSCs. In this study, we could not find the condition of production of microcapsule with cancer stem cell-specific antibody on outer lumen. On the other hand, the proportion of CD133 positive cells increased by incubation under hypoxia. For synergistic effect , X-irradiation combined with hypoxia enhanced the induction of CD133 positive fraction In contrast, treatment with larger fraction dose revealed no additional effect on induction of CD133 positive fraction.This study suggests that the synergistic effect of X-irradiation on modulation of hypoxia-induced CD133+ population depends on the irradiated dose. Radiotherapy with an appropriate large fraction dose such as stereotactic radiotherapy has the possibility of maximized suppressive effect on CSCs induced by cancer treatment itself.
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