| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Some types of spacer for injection are commercially available and surgical implantation of spacer for radiotherapy has been reported. However, surgical implantation has a probability of infection and it is difficult to insert it in appropriate site. Therefore, we try to find materials which can be injected under CT guidance safely as spacer. we focused gelatin polymer gel (RM-100HS, Kanto Kagaku), which had been used for vascular embolization. Five mice received injection of 0.3 cc of that gelatin polymer gel into the back subcutaneous tissue. CT scan were obtained at day 0, 1, 3, 7, 14, 21 and 35. In first 24 hours, the volume increased 112±31%. The volume of gel was stable between day 1 and day 21, with volume change between -11% and +15%. At day 35 after injection, major variation of the volume was observed. During the observation period, no major toxic effect was observed macroscopically and histologically.
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