Development of percutaneous inserting absorbable spacer for radiotherapy
| Project/Area Number |
26860970
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
Jingu Keiichi 東北大学, 医学系研究科, 教授 (00451592)
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| Research Collaborator |
TAKEDA Kazuya
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線治療 / スペーサー / 吸収型 / 経皮的に挿入可能な体内吸収型のスペーサー / 吸収型スペーサー / 経皮注入吸収型スペーサー / 体幹部定位放射線治療 |
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| Outline of Final Research Achievements |
Some types of spacer for injection are commercially available and surgical implantation of spacer for radiotherapy has been reported. However, surgical implantation has a probability of infection and it is difficult to insert it in appropriate site. Therefore, we try to find materials which can be injected under CT guidance safely as spacer. we focused gelatin polymer gel (RM-100HS, Kanto Kagaku), which had been used for vascular embolization. Five mice received injection of 0.3 cc of that gelatin polymer gel into the back subcutaneous tissue. CT scan were obtained at day 0, 1, 3, 7, 14, 21 and 35. In first 24 hours, the volume increased 112±31%. The volume of gel was stable between day 1 and day 21, with volume change between -11% and +15%. At day 35 after injection, major variation of the volume was observed. During the observation period, no major toxic effect was observed macroscopically and histologically.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer.2017
Author(s)
Jingu K, Matsuo Y, Onishi H, Yamamoto T, Aoki M, Murakami Y, Yamashita H, Kakuhara H, Nemoto K, Sakayauchi T, Okamoto M, Niibe Y, Nagata Y, Ogawa K.
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Journal Title
Anticancer Res.
Volume: 37
Pages: 2709-2713
Related Report
Peer Reviewed
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[Journal Article] Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base.2016
Author(s)
Koto M, Hasegawa A, Takagi R, Ikawa H, Naganawa K, Mizoe JE, Jingu K, Tsujii H, Tsuji H, Kamada T, Okamoto Y
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Journal Title
Head Neck.
Volume: 印刷中
Issue: S1
DOI
Related Report
Peer Reviewed
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