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Examining feasibility of brain MRI as an objective diagnostic biomarker for glaucoma

Research Project

Project/Area Number 26860971
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

Tatewaki Yasuko  東北大学, 加齢医学研究所, 助教 (40722202)

Research Collaborator Nakazawa Toru  東北大学, 医学部, 教授
Omodaka Kazuko  東北大学, 病院, 助教
Tomita Hiroaki  東北大学, 災害科学国際研究所, 教授
Ono Chiaki  東北大学, 災害科学国際研究所, 助教
Kasahara Yoshiyuki  東北大学, 災害科学国際研究所, 助教
Matsudaira Izumi  東北大学, 加齢医学研究所, 大学院生
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳MRI / 客観的評価 / 緑内障 / MRI / BDNF / 遺伝子多型
Outline of Final Research Achievements

We have been conducted longitudinal data aquisition and have analyzed cross-sectional data including mainly anatomical 3D-T1WI images and clinical visual field information, MD(mean deviation). Voxel-based regressing analysis with SPM12(Statistical Parametric Mapping software 12) revealed that gray matter volume of the specific region in primary visual cortex could correspond to the degree of glaucoma-related visual field loss. Patients with glaucoma are often unaware of their visual field loss because that glaucoma-related visual sensitivity loss starts from periphery of visual field. Our results could be of clinical use for picking up asymptomatic glaucoma by detecting specific atrophy via brain MRI medical checkup.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015

All Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 7 results) Presentation (8 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] "Posterior associative and cingulate cortex involvement of brain single-photon emission computed tomography (SPECT) imaging in semantic dementia with probable Alzheimer disease pathology: A case report2018

    • Author(s)
      Takano Y, Kunitoki K, Tatewaki Y, Mutoh T, Totsune T, Shimomura H, Nakagawa M, Arai H, Taki Y.
    • Journal Title

      Am J Case Rep

      Volume: 19 Pages: 153-157

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of low-grade primary cardiac lymphoma with pericardial effusion diagnosed by combined 18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) imaging and effusion cytology2018

    • Author(s)
      Fukunaga H, Tatewaki Y, Mutoh T, Shimomura H, Yamamoto S, Terao C, Totsune T, Nakagawa M, Taki Y.
    • Journal Title

      Am J Case Rep

      Volume: 19 Pages: 262-265

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage2018

    • Author(s)
      Mutoh T, Sasaki K, Tatewaki Y, Kunitoki K, Takano Y, Taki Y.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 45 Pages: 344-348

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duplicated internal auditory canal with inner ear malformation: Case report and literature review2018

    • Author(s)
      Takanashi Y, Kawase T, Tatewaki Y, Suzuki J, Yahata I, Nomura Y, Oda K, Miyazaki H, Katori Y.
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Pages: 351-357

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced CBF recovery detected by longitudinal 3D-SSP SPECT analyses predicts outcome of postoperative patients after subarachnoid haemorrhage2018

    • Author(s)
      Mutoh T, Totsune T, Takenaka S, Tatewaki Y, Nakagawa M, Suarez JI, Taki Y, Ishikawa T.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 45 Pages: 127-132

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知症のMRI診断(VSRADを含む)2018

    • Author(s)
      舘脇康子, 瀧靖之.
    • Journal Title

      日本臨床増刊号

      Volume: 76 Pages: 16-23

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Phase difference-enhanced magnetic resonance imaging (PADRE) technique for the detection of age-related microstructural changes in optic radiation: Comparison with diffusion tensor imaging2017

    • Author(s)
      Tatewaki Y, Mutoh T, Thyreau B, Omodaka K, Murata T, Sekiguchi A, Nakazawa T, Taki Y.
    • Journal Title

      Med Sci Monit

      Volume: 23 Pages: 5495-5503

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuro-myelomatosis of the brachial plexus - An unusual site of disease visualized by FDG-PET/CT: A case report2017

    • Author(s)
      Fukunaga H, Mutoh T, Tatewaki Y, Shimomura H, Totsune T, Terao C, Miyazawa H, Taki Y.
    • Journal Title

      Am J Case Rep

      Volume: 18 Pages: 478-481

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Recurrence in Resected Pancreatic Ductal Adenocarcinoma2017

    • Author(s)
      Ariake K, Motoi F, Shimomura H, Mizuma M, Maeda S, Terao C, Tatewaki Y, Ohtsuka K, Fukase K, Matsuda K, Hayashi H, Takadate T, Naitoh T, Taki Y, Unno M
    • Journal Title

      J Gastrointest Surge

      Volume: 22 Pages: 279-287

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inotropic support against early brain injury improves cerebral hypoperfusion and outcomes in a murine model of subarachnoid hemorrhage2017

    • Author(s)
      9.Mutoh T, Mutoh T, Nakamura K, Sasaki K, Tatewaki Y, Ishikawa T, Taki Y.
    • Journal Title

      Brain Res Bull

      Volume: 130 Pages: 18-26

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurocardiac protection with milrinone for restoring acute cerebral hypoperfusion and delayed ischemic injury after experimental subarachnoid hemorrhage.2017

    • Author(s)
      Mutoh T, Mutoh T, Sasaki K, Nakamura K, Tatewaki Y, Ishikawa T, Taki Y.
    • Journal Title

      Neurosci Lett.

      Volume: 640 Pages: 70-75

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuro-Myelomatosis of the brachial plexus-An unusual site of disease visualized by Fluorodeoxyglucose-Positron Emission Tomography/COmputed tomography (FDG-PET/CT): A case report2017

    • Author(s)
      Fukunaga H, Mutoh T, Tatewaki Y, Shimomura H, Totsune T, Terao C, Miyazawa H, Taki Y
    • Journal Title

      Am J Case Rep.

      Volume: 18

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inotropic support against early brain injury improves cerebral hypoperfusion and outcomes in a murine model of subarachnoid hemorrhage.2016

    • Author(s)
      Mutoh T, Mutoh T, Nakamura K, Sasaki K, Tatewaki Y, Ishikawa T, Taki Y.
    • Journal Title

      Brain Res Bull

      Volume: 130 Pages: 18-26

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient Hearing Loss and Objective Tinnitus Induced by Mouth Opening: A Rare Connection Between the Temporomandibular Joint and Middle Ear Space.2016

    • Author(s)
      Hidaka H, Tatewaki Y, Sakamoto M, Kobayashi T, Yuasa Y, Yuasa R, Nomura K, Yamauchi D, Katori Y.
    • Journal Title

      Otol Neurotol.

      Volume: 37

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan.2016

    • Author(s)
      Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Kato Y, Tatewaki Y, Takase K, Kushimoto S, Tominaga T, Takahashi S.
    • Journal Title

      Springerplus.

      Volume: 5 Pages: 176-176

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly.2015

    • Author(s)
      Oikawa T, Tatewaki Y, Murata T, Kato Y, Mugikura S, Takase K, Takahashi S.
    • Journal Title

      Neuroradiol J.

      Volume: 28(6) Issue: 6 Pages: 628-633

    • DOI

      10.1177/1971400915609334

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] MRIにおける広範な脳視覚野の緑内障性変化と部位間の相関2017

    • Author(s)
      福田 麻奈, 面高 宗子, 舘脇 康子, 檜森 紀子, 松平 泉, 村田 隆紀, 瀧 靖之, 中澤 徹
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2017-04-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Investigation for clinical significance of Eyeball Volume in Glaucoma: an MRI study2017

    • Author(s)
      Keiko Kunitoki, Yasuko Tatewaki, Akihiro Furukawa, Benjamin Thyreau, Kazuko Omodaka, Izumi Matsudaira, Tatsushi Mutoh, Ryuta Kawashima, Toru Nakazawa, and Yasuyuki Taki.
    • Organizer
      European Congress of Radiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRIにおける眼窩内視神経断面積の緑内障性変化2016

    • Author(s)
      福田 麻奈, 面高 宗子, 舘脇 康子, 檜森 紀子, 松平 泉, 村田 隆紀, 瀧 靖之, 中澤 徹
    • Organizer
      日本緑内障学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] MRIにおける脳一次視覚野の緑内障性変化2016

    • Author(s)
      面高 宗子, 福田 麻奈, 舘脇 康子, 檜森 紀子, 松平 泉, 村田 隆紀, 瀧 靖之, 中澤 徹
    • Organizer
      日本緑内障学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] シンポジウム8(緑内障の進行判定と評価) MRIによる進行判定2015

    • Author(s)
      面高 宗子
    • Organizer
      第69回 日本臨床眼科学会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 位相差強調画像化法を用いた健常者視放線のvolumetryによる加齢変化の検討2015

    • Author(s)
      舘脇 康子
    • Organizer
      第43回 日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル、東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Age-related change of Optic Radiation: Quantitative volumetric analysis with Tissue enhanced SWIp2015

    • Author(s)
      Yasuko Tatewaki, Izumi Matsudaira, Yasuyuki Taki, kazuko Omodaka, Toru Nakazawa et.al.
    • Organizer
      OHBM(Organization for Human Brain Mapping)
    • Place of Presentation
      Honolulu, US
    • Year and Date
      2015-06-14 – 2015-06-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Age related chanage of the Optic Radiation: Quantitative volumetric analysis with Tissue enhanced SWIp2015

    • Author(s)
      舘脇 康子
    • Organizer
      OHBM Organization of Human Brain Mapping
    • Place of Presentation
      Waikiki, US
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 前視野緑内障に向き合う2016

    • Author(s)
      中澤徹 他
    • Total Pages
      240
    • Publisher
      文光堂
    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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