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Synthesis and biological evaluation of 18F-FIBG as a PET imaging agent for the detection of pheochromocytoma

Research Project

Project/Area Number 26860981
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

Yamaguchi Aiko  群馬大学, 医学(系)研究科(研究院), 特任助教 (80609032)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsPET / 褐色細胞腫 / MIBG
Outline of Final Research Achievements

The aim of this study was to develop an improved method for the radiolabeling of 18F-FIBG, a 18F labeled analog of MIBG, and evaluate its potential as a PET imaging agent for the detection of pheochromocytoma. Hetero-diaryliodonium salt of N-Boc protected diiodobenzylguanidine was synthesized as a labeling precursor. The two-step conversion from the precursor readily produced 18F-FIBG. The PET image revealed visible 18F-FIBG uptake in the tumor in the subcutaneous pheochromocytoma xenograft mice. Above all, 18F-FIBG constitutes a promising PET pheochromocytoma-imaging agent.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Toward convenient synthesis of 18F labeled MIBG analogs2015

    • Author(s)
      山口藍子、花岡宏史、樋口徹也、対馬義人
    • Organizer
      The 2015 International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2017-05-10  

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