Synthesis and biological evaluation of 18F-FIBG as a PET imaging agent for the detection of pheochromocytoma

Research Project

Project/Area Number	26860981
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Gunma University
Principal Investigator	Yamaguchi Aiko 群馬大学, 医学(系)研究科(研究院), 特任助教 (80609032)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	PET / 褐色細胞腫 / MIBG
Outline of Final Research Achievements	The aim of this study was to develop an improved method for the radiolabeling of 18F-FIBG, a 18F labeled analog of MIBG, and evaluate its potential as a PET imaging agent for the detection of pheochromocytoma. Hetero-diaryliodonium salt of N-Boc protected diiodobenzylguanidine was synthesized as a labeling precursor. The two-step conversion from the precursor readily produced 18F-FIBG. The PET image revealed visible 18F-FIBG uptake in the tumor in the subcutaneous pheochromocytoma xenograft mice. Above all, 18F-FIBG constitutes a promising PET pheochromocytoma-imaging agent.

Report

(3 results)