Establish of the muscle fiber type identification method by q-space imaging

• Project/Area Number: 26860982
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: Hata Junichi 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 (00568868)
• Research Collaborator: HIKISHIMA Keigo 沖縄科学技術大学院大学 ; FUJIYOSHI Kanehiro 慶應義塾大学, 整形外科教室
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 磁気共鳴画像法 / パルスシーケンス / 拡散強調画像 / 制限拡散 / q-space imaging / 骨格筋 / 筋線維 / 高磁場MRI

Outline of Final Research Achievements

The purpose of this study is to establish a method for sorting the skeletal muscle fibers type by q-space imaging. This method can acquire microstructure information of living tissue. Based on this information, we establish a method to make the type of skeletal muscle fibers noninvasive and easy to distinguish. As a result, it became possible to analyze the displacement amount in the microstructure of the water molecule, and it was possible to acquire the microsized structural information of the living tissue. In addition, compared with stained images of skeletal muscle of mouse lower thigh, comparison with the skeletal muscle type distribution in axillary cross section image of the mice's lower leg, and comparison with muscle cell diameter, significant correlation was obtained. It was confirmed as a novel technique as a method of identifying the muscle fiber type.

Research Products

• [Journal Article] q-Space Myelin Map imaging for longitudinal analysis of demyelination and remyelination in multiple sclerosis patients treated with fingolimod: A preliminary study (2017)
  • Author(s): Mariko Tanikawa, Jin Nakahara, Junichi Hata, Shigeaki Suzuki, Kanehiro Fujiyoshi, Hirokazu Fujiwara, Suketaka Momoshima, Masahiro Jinzaki, Masaya Nakamura, Hideyuki Okano, Shinichi Takahashi, Norihiro Suzuki
  • Journal Title: J Neurol Sci Volume: 15 Pages: 352-357
  • DOI: 10.1016/j.jns.2017.01.009
  • Peer Reviewed
• [Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter (2016)
  • Author(s): Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
  • Journal Title: Journal of Neuroscience Volume: 36(9) Issue: 9 Pages: 2796-2808
  • DOI: 10.1523/jneurosci.1770-15.2016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Human Skeletal Muscle Contraction and Force by Diffusion Tensor Imaging (2015)
  • Author(s): Hata, J. , Nagata, H. , Endo, K. , Komaki, Y. , Sato, M. , Numano, T. and Yagi, K
  • Journal Title: Open Journal of Radiology Volume: 5 Issue: 04 Pages: 189-198
  • DOI: 10.4236/ojrad.2015.54026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Q-space Imaging Is A Novel Technique To Evaluate Intervertebral Disc Degeneration (2017)
  • Author(s): Daisuke Nakashima, Nobuyuki Fujita, Junichi Hata, Takeo Nagura, Kanehiro Fujiyoshi, Hideyuki Okano, Masahiro Jinzaki, Morio Matsumoto, Masaya Nakamura
  • Organizer: Orthopaedic Research Society 2017 Annual Meeting
  • Place of Presentation: San Diego, California
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] Understanding Marmoset Neural Architecture using Ultra High Field MRI (2017)
  • Author(s): Junichi Hata, Akiko Uematsu, Takaaki Kaneko, Makoto Fukushima, Fumiko Seki, Yuji Komaki, Yawara Haga, Yukiko Nagawa, Erika Sasaki, and Hideyuki Okano
  • Organizer: International Society of Magnetic Resonance in Medicine Japanese Chapter 1st Annual Scientific Meeting
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2017-02-23
  • Int'l Joint Research
• [Presentation] Postmortem MRI properties of common marmoset brain during formalehyde-fixed (2016)
  • Author(s): Yawara Haga, Junichi Hata, Akiko Uematsu, Takaaki Kaneko, Yukiko Nagawa, Marin Nishio, Yuji Komaki, Fumiko Seki, Noriyuki Kishi, Erika Sasaki, Hideyuki Okano and Akira Furukawa
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮、日本
  • Year and Date: 2016-09-13
• [Presentation] Depiction of Neural Microstructures by Ultra High Field MRI (2016)
  • Author(s): Junichi Hata, Akiko Uematsu, Takaaki Kaneko, Makoto Fukusima, Fumiko Seki, Yuji Komaki, Yukiko Nagawa, Keigo Hikishima, Noriyuki Kishi, Erika Sasaki, Hideyuki Okano
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮、日本
  • Year and Date: 2016-09-12
• [Presentation] 超高磁場MRIを用いたマーモセット脳神経構造の評価 (2016)
  • Author(s): 畑純一，兼子峰明，植松明子，関布美子，小牧裕司，矢野竜太郎，名川由紀子，岸憲行，佐々木えりか，岡野栄之
  • Organizer: 日本マーモセット研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-01-27
• [Presentation] Structural and Functional Mapping of the Marmoset Brain Using MRI (2015)
  • Author(s): Takaaki Kaneko, Junichi Hata, Noriyuki Kishi, Hideyuki Okano
  • Organizer: Advances in Neuroinformatics
  • Place of Presentation: Tokyo
  • Year and Date: 2015-11-26
  • Int'l Joint Research
• [Presentation] 独自MR elastographyシステムの特徴と制限・限界点 (2015)
  • Author(s): 沼野智一，水原和行，伊東大輝，大西孝明，畑 純一，高本孝一，西条寿夫
  • Organizer: 日本放射線技術学会秋季大会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-08
• [Presentation] Long Diffusion Timeにおける骨格筋拡散信号の挙動 (2015)
  • Author(s): 畑 純一，佐藤正和，矢野竜太朗，小牧裕司，疋島啓吾，藤吉兼浩，中村雅也，岡野栄之
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] モンテカルロシミュレーションを用いた生体内微細制限構造における拡散最適条件の推定 (2015)
  • Author(s): 佐藤正和，畑 純一，八木一夫，立花泰彦，関根紀夫
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] 超高磁場拡散MRIで脱髄を追う (2015)
  • Author(s): 矢野竜太朗，畑 純一，関布美子，石原良祐，小牧裕司，疋島啓吾，田中謙二，岡野栄之
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] 透明化による脳組織変性の評価 (2015)
  • Author(s): 名川友紀子，畑 純一，矢野竜太朗，関布美子，小牧裕司，八木一夫，関根紀夫
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] DTIを用いた筋力発揮時における羽状筋構造解析 (2015)
  • Author(s): 八木一夫，新川翔太，畑 純一，遠藤和樹
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-10
• [Presentation] A retrofit Technology for MR Elastography (2015)
  • Author(s): Tomokazu Numano, Kawabata Yoshihiko, Kazuyuki Mizuhara, Toshikatu Washio, Junichi Hata, Kazuhiro Homma
  • Organizer: Scientific Meeting &Exhibition ISMRM
  • Place of Presentation: Tronto
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Pilot longitudinal follow-up study of Myelin Map in multiple sclerosis (2015)
  • Author(s): 谷川万里子, 中原仁, 藤吉兼浩, 疋島啓吾, 畑 純一, 百島祐貴, 高橋愼一, 岡野栄之, 中村雅也, 鈴木則宏
  • Organizer: 日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-11
• [Presentation] 拡散シミュレーションによる生体内微細制限構造における水分子の挙動推定 (2015)
  • Author(s): 佐藤正和，八木一夫，畑 純一，丹綾香
  • Organizer: 日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-16
• [Presentation] 7T MRIによる骨格筋の高分解能拡散イメージング (2014)
  • Author(s): 畑 純一
  • Organizer: 第42回 日本磁気共鳴医学会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-14