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The analisis of clinical condition of IgG4-related disease with using imaging examinations

Research Project

Project/Area Number 26860986
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

Inoue Dai  金沢大学, 大学病院, 助教 (00645129)

Research Collaborator Matsui Osamu  
Gabata Toshifumi  
Zen Yoh  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsIgG4-related disease / CT / MRI / IgG4関連疾患 / FDG-PET / 血清IgG4 / ステロイド
Outline of Final Research Achievements

IgG4-related disease is a recently established systemic disease entity and overall picture of it has been unclear. In this research, we collected 235 cases with IgG4-related disease and retrospectively reviewed clinical notes and imaging examinations to reveal the organ manifestation in each patients.

As a result, we revealed that all patients were adults (M/F 4/1) and 90% of the patients were diagnosed in their 50s to 70s. Among all manifestations identified in total, the most common was pancreas, followed by submandibular gland, kidney, lacrimal gland, and aorta. The majority (95%) of patients had at least 1 one the 5 most common manifestations. Male and female patients differed in their organ manifestations. Corticosteroid therapy was effective, but recurrence was seen in 24% of in the study period.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report

Research Products

(21 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results)

  • [Journal Article] 「IgG4関連疾患の胸部画像」2016

    • Author(s)
      井上 大、南 哲弥、小坂一斗、北尾 梓、米田憲秀、吉田耕太郎、池野 宏、戸島史仁、松井 修、蒲田敏文
    • Journal Title

      日本胸部臨床

      Volume: 75(3) Pages: 247-55

    • Related Report
      2015 Annual Research Report
  • [Journal Article] IgG4-related disease: Dataset of 235 consecutive patients.2015

    • Author(s)
      Inoue D, Yoshida K, Yoneda K., et al.
    • Journal Title

      Medicine (Baltimore).

      Volume: /

    • DOI

      10.1097/md.0000000000000680

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics.2015

    • Author(s)
      Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Sanada J, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Nakanuma Y, Kita R, Gabata T.
    • Journal Title

      Radiology

      Volume: 275 Pages: 708-17

    • DOI

      10.1148/radiol.14141315

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease.2015

    • Author(s)
      Inoue K, Okubo T, Kato T, Shimamura K, Sugita T, Kubota M, Kanaya K, Yamachika D, Sato M, Inoue D, Harada K, Kawano M.
    • Journal Title

      Mod Rheumatol.

      Volume: Sep 18 Pages: 1-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pericardial Involvement in IgG4-related Disease2015

    • Author(s)
      Mori K, Yamada K, Konno T, Inoue D, Uno Y, Watanabe M, Okuda M, Oe K, Kawano M, Yamagishi M
    • Journal Title

      Intern. Med.

      Volume: 54 Issue: 10 Pages: 1231-1235

    • DOI

      10.2169/internalmedicine.54.3856

    • NAID

      130005069788

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「IgG4関連疾患の画像所見」2015

    • Author(s)
      井上 大、南 哲弥、小坂一斗、北尾 梓、米田憲秀、吉田耕太郎、松井 修、蒲田敏文
    • Journal Title

      モダンフィジシャン

      Volume: 35(11) Pages: 1307-11

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 「自己免疫性膵炎20年の軌跡;CT/MRIで診断可能か?」2015

    • Author(s)
      井上 大、蒲田敏文
    • Journal Title

      肝胆膵

      Volume: 70(2) Pages: 259-66

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 自己免疫性膵炎20年の軌跡;CT/MRIで診断可能か?2015

    • Author(s)
      井上 大,蒲田敏文.
    • Journal Title

      肝胆膵

      Volume: 70(2) Pages: 259-266

    • Related Report
      2014 Research-status Report
  • [Journal Article] Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study.2014

    • Author(s)
      Mizushima I, Inoue D, Yamamoto M, Yamada K, Saeki T, Ubara Y, Matsui S, Masaki Y, Wada T, Kasashima S, Harada K, Takahashi H, Notohara K, Nakanuma Y, Umehara H, Yamagishi M, Kawano M.
    • Journal Title

      Arthiritis Res Ther.

      Volume: 16

    • DOI

      10.1186/ar4671

    • NAID

      120006460360

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 消化器MRIの読み方:自己免疫性膵炎のMRI診断.2014

    • Author(s)
      井上 大,全 陽,小林 聡ら.
    • Journal Title

      臨牀消化器内科

      Volume: 29 Pages: 1514-1519

    • Related Report
      2014 Research-status Report
  • [Presentation] 「膵炎症性偽腫瘍,腫瘍類似病変の画像診断」2016

    • Author(s)
      井上 大
    • Organizer
      第35回日本画像医学会
    • Place of Presentation
      ステーションコンファレンス東京(東京)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] The Imaging Features of IgG4-related disease with pathologic correlation.2015

    • Author(s)
      Inoue D,Yoh Zen, Satoshi Kobayashi, Kotaro Yoshida, Norihide Yoneda, Tetsuya Minami, Azusa Kitao, Kazuto Kozaka, Osamu Matsui, Toshifumi Gabata.
    • Organizer
      101th Radiological Society of North America
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「IgG4関連疾患の画像所見」2015

    • Author(s)
      井上 大
    • Organizer
      第83回比叡山カンファレンス
    • Place of Presentation
      メルパルク京都(京都)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 「IgG4関連疾患の画像所見」2015

    • Author(s)
      井上 大
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Gastric lesion of IgG4-related disease; A case report.2015

    • Author(s)
      Inoue D, Satoshi Kobatashi, Tetsuya Minami, Kazuto Kozaka, Azusa Kitao, Norihide Yoneda, Kotaro YOshida, Mitsuhiro Kawano, Jun Kinoshita, Hiroko Ikeda, Toshifumi Gabata
    • Organizer
      5th Asian Congress of Abdominal Radiology
    • Place of Presentation
      アクトシティ浜松(静岡、浜松)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「泌尿器科領域のIgG4関連疾患」2015

    • Author(s)
      井上 大
    • Organizer
      第103回日本泌尿器学会総会
    • Place of Presentation
      ANAクラウンプラザ金沢(石川、金沢)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IgG4関連後腹膜線維症の臨床画像病理学的検討2015

    • Author(s)
      井上 大、小林 聡、小坂一斗、北尾 梓、米田憲秀、吉田耕太郎、戸島史仁、蒲田敏文
    • Organizer
      日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinicoradiollogical features of the retroperitoneal fibrosis in IgG4-related disease.2015

    • Author(s)
      Inoue D, Kobayashi S, Minami T., et al.
    • Organizer
      European Congress of radiology (ECR) 2015
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-03-04 – 2015-03-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 「IgG4関連疾患の画像所見」2014

    • Author(s)
      井上 大
    • Organizer
      第72回香川画像診断談話会
    • Place of Presentation
      マリンパレスさぬき、香川
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 「胸腹部領域のIgG4関連疾患の画像所見」2014

    • Author(s)
      井上 大
    • Organizer
      第23回 山陽MR研究会
    • Place of Presentation
      岡山国際交流センター
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The benign lesions which need to be distinguished from pancreatic cancer.2014

    • Author(s)
      井上 大
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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