Development of new radiopharmaceuticals targeting amino acid transporter system ASC, and system N
| Project/Area Number |
26860988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
NISHI Kodai 長崎大学, 原爆後障害医療研究所, 助教 (10719496)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Masato 金沢大学, 健康増進科学センター, 助教 (30444235)
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| Research Collaborator |
NIWA Takahiro
INAGAWA Kohei
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | アミノ酸トランスポーター / System N / ヒスチジン / ヨウ素標識 / 小動物イメージング |
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| Outline of Final Research Achievements |
The aim of study is development of new radiopharmaceutical targeting amino acid transporter system ASC, and system N. Our research group discovered that system N transports the L-histidine(L-His) using our original screening system.
We tried iodine labeling for L-His because L-His was evaluated with promising results as base compound of new radiopharmaceutical targeting system N. As a result, high purity 125I-iodo-L-His(125I-IH) was defecated. According to experiment results, most of 125I-IH was transported into the cells by system L, however system N contributed 15% to transportation of 125I-IH in several tumor cell lines.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Tofla virus: A newly identified Nairovirus of the Crimean-Congo hemorrhagic fever group isolated from ticks in Japan.2016
Author(s)
Shimada S, Aoki K, Nabeshima T, Fuxun Y, Kurosaki Y, Shiogama K, Onouchi T, Sakaguchi M, Fuchigami T, Ono H, Nishi K, Posadas-Herrera G, Uchida L, Takamatsu Y, Yasuda J, Tsutsumi Y, Fujita H, Morita K, Hayasaka D.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 20213-20213
DOI
NAID
Related Report
Peer Reviewed / Open Access
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