Gd-EOB-DTPA enhanced MRI findings of hepatocellular carcinoma with beta-catenin mutation

• Project/Area Number: 26860989
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: Kitao Azusa 金沢大学, 大学病院, 助教 (20608690)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肝細胞癌 / MRI / Gd-EOB-DTPA / β-catenin

Outline of Final Research Achievements

Hepatocellular carcinoma (HCC) with β-catenin mutation showed high ADC value and high enhancement ratio on Gd-EOB-DTPA enhanced MR imaging. β-catenin mutated HCC showed lower AFP value, frequent pseudoglandular proliferation pattern with bile production and higher grade of differentiation. Such imaging findings will be useful to diagnose this less aggressive subtype of HCC.

Research Products

• [Journal Article] Hepatocellular Carcinoma with β-Catenin Mutation: Imaging and Pathologic Characteristics (2015)
  • Author(s): Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Sanada J, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Nakanuma Y, Kita R, Gabata T
  • Journal Title: Radiology Volume: -
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肝細胞癌のEOB-MRI所見と癌抑制因子HNF4α発現との相関 (2016)
  • Author(s): 北尾 梓、松井 修、米田憲秀、小坂一斗、小林 聡、吉田耕太郎、井上 大、南 哲弥、香田 渉、山下太郎、山下竜也、金子周一、蒲田敏文
  • Organizer: 第20回 肝血流動態・機能イメージ研究会
  • Place of Presentation: 東京ビッグサイト（東京）
  • Year and Date: 2016-02-05
• [Presentation] Current status of imaging biomarker in hepatocellular carcinoma: from radioproteomics to radiogenomics (2015)
  • Author(s): Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Toshifumi Gabata
  • Organizer: RSNA (Radiological Society of North America)
  • Place of Presentation: McCormick Place, Chicago
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] A tumor suppression factor HNF4α expression correlates with gadoxetic acid enhanced MRI findings in hepatocellular carcinoma (2015)
  • Author(s): Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Toshifumi Gabata
  • Organizer: RSNA (Radiological Society of North America)
  • Place of Presentation: McCormick Place, Chicago
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] β-catenin 変異型肝細胞癌の画像所見および病理学的特徴 (2015)
  • Author(s): 北尾 梓、松井 修、蒲田敏文、米田憲秀、小坂一斗、小林 聡、吉田耕太郎、井上 大、南 哲弥、香田 渉、眞田順一郎、池田博子、中沼安二、山下太郎、金子周一、高村博之、太田哲生、喜多竜一
  • Organizer: 第51回 日本肝癌研究会
  • Place of Presentation: 神戸国際会議場、ポートピアホテル（神戸）
  • Year and Date: 2015-07-23
• [Presentation] Imaging and pathological characteristics of hepatocellular carcinoma with β-catenin mutation (2015)
  • Author(s): Azusa Kitao, Osamu Matsui, Toshifumi Gabata, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Junichiro Sanada, Yasuni Nakanuma, Taro Yamashita, Shuichi Kaneko
  • Organizer: The 6th asia pacific primary liver cancer expert meeting
  • Place of Presentation: ハイアットリージェンシー大阪（大阪）
  • Year and Date: 2015-07-03
  • Int'l Joint Research
• [Presentation] Imaging and pathological characteristics of hepatocellular carcinoma with β-catenin mutation (2015)
  • Author(s): Azusa Kitao, Osamu Matsui, Toshifumi Gabata, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Junichiro Sanada, Yasuni Nakanuma, Taro Yamashita, Shuichi Kaneko
  • Organizer: 5th Asian Congress of Abdominal Radiology
  • Place of Presentation: アクトシティ浜松（浜松）
  • Year and Date: 2015-06-19
  • Int'l Joint Research
• [Presentation] 肝細胞癌のEOB-MRI所見とHNF4α発現との相関 (2015)
  • Author(s): 北尾 梓、松井 修、米田憲秀、小坂一斗、小林 聡、吉田耕太郎、井上 大、南 哲弥、香田 渉、蒲田敏文
  • Organizer: 第74回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2015-04-16
• [Presentation] 肝細胞癌のMRI (2015)
  • Author(s): 北尾 梓
  • Organizer: 1st Radiology Today in OKAYAMA
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
  • Year and Date: 2015-01-31
  • Invited
• [Presentation] Imaging and biological characteristics of hepatocellular carcinoma with β-catenin mutation (2014)
  • Author(s): Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Junichiro Sanada, Yasuni Nakanuma, Taro Yamashita, Shuichi Kaneko, Toshifumi Gabata
  • Organizer: Radiological Society of North America 2014
  • Place of Presentation: McCormick place（Chicago）
  • Year and Date: 2014-11-29 – 2014-12-04
• [Presentation] Correlation between gadoxetic acid enhanced MR imaging and molecular/genetic background of hepatocellular carcinoma: Implication for radiogenomics (2014)
  • Author(s): Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Wataru Koda, Junichiro Sanada, Yasuni Nakanuma, Taro Yamashita, Shuichi Kaneko, Toshifumi Gabata
  • Organizer: Radiological Society of North America 2014
  • Place of Presentation: McCormick place（Chicago）
  • Year and Date: 2014-11-29 – 2014-12-04
• [Presentation] 肝細胞癌のGd-EOB-DTPA造影MRI：Radiogenomicsの可能性 (2014)
  • Author(s): 北尾 梓
  • Organizer: 第50回日本医学放射線学会 秋季臨床大会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
  • Year and Date: 2014-09-26 – 2014-09-28
  • Invited
• [Presentation] 肝癌多段階発癌と早期肝癌のGd-EOB-DTPA造影MRI所見：分子病理学的背景からの考察 (2014)
  • Author(s): 北尾 梓、松井 修、米田憲秀、小坂一斗、小林 聡、蒲田敏文、山下太郎、荒井邦明、山下竜也、金子周一、中沼安二
  • Organizer: 第50回 日本肝癌研究会
  • Place of Presentation: 国立京都国際会館（京都府）
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] β-catenin変異型肝細胞癌の画像所見および組織学的特徴の検討 (2014)
  • Author(s): 北尾 梓、松井 修、米田憲秀、小坂一斗、小林 聡、井上 大、南 哲弥、龍 泰治、香田 渉、蒲田 敏文
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-04-10 – 2014-04-13